美沙酮维持治疗前后阴道黏膜表面免疫球蛋白及唾液免疫球蛋白水平的变化  

Immunoglobulin Level Changes of Vaginal Mucosa Surface and Salivary before and after Methadone Maintenance Treatment

作　　者：姚峻 李佳妍 石珊 蔡彦 YAO Jun;LI Jia-yan;SHI shan;CAI Yan(Nanning City Red Cross Hospital,Nanning,Guangxi,530012)

机构地区：[1]南宁市红十字会医院,广西南宁530012

出　　处：《智慧健康》2018年第18期61-62,64,共3页Smart Healthcare

基　　金：广西南宁市科技资金资助项目(编号:20143148)

摘　　要：目的探讨美沙酮维持治疗前后阴道黏膜表面免疫球蛋白、唾液免疫球蛋白水平指标变化。方法将210例海洛因依赖患者设为实验组,均给予美沙酮维持治疗,根据剂量不同分为Ⅰ组和Ⅱ组,每组105名,Ⅰ组给予美沙酮40-59 mg/d,Ⅱ组给予60-80 mg/d。同等例数健康体检者设为对照组,根据美沙酮维持剂量平均分为两组:对照组治疗前、MMT两组治疗前、治疗12个月取阴道分泌物及唾液标本。比较实验组MMT前后阴道黏膜表面免疫球蛋白(sIgA)水平、唾液标本免疫球蛋白(sIgA)水平指标变化,并分别与健康对照组进行比较。结果美沙酮治疗组治疗前阴道黏膜表面sIgA为(0.645.35±0.175)(g/L),与治疗后sIgA 0.352±0.182 g/L比较,有显著差异(P<0.05);唾液标本治疗前sIgA(788.3±102.5)(μg/mL),治疗后(367.4±47.3)(μg/mL),前后相比,有非常显著性差异(P<0.01)。结论海洛因依赖者经过美沙酮维持治疗后,机体免疫功能、黏膜免疫者水平逐渐恢复;治疗效果与投药剂量有关系。Objective to investigate immunoglobulin level changes of vaginal mucosa surface and salivary before and after methadone maintenance treatment. Methods treat 210 cases heroin dependent patients as experimental group, with methadone maintenance treatment. According to different dosage, divide them into group Ⅰ and Ⅱ, 105 cases in each. Group Ⅰ was treated with methadone 40-59 mg/d, and group Ⅱ with 60-80 mg/d. Choose same cases of healthy checkup persons as control group, divide them into two groups in average based on methadone maintenance dosage. Collect vaginal discharge and saliva specimens before treatment, before MMT treatment, 12 months after treatment. Compare immunoglobulin（sIgA） level changes of vaginal mucosa surface and salivary of experimental group before and after MMT, compare them with healthy control group. Results SIgA of vaginal mucosa surface was（0.645.35±0.175）（g/L） of methadone treatment group before treatment, and that after treatment was（0.352±0.182 g/L）, with significant difference（P〈0.05）. SIgA of saliva specimens before treatment was（788.3±102.5）（μg/mL）, and that after treatment was（367.4±47.3）（mu g/mL）, with significant difference between before and after treatment,（P〈0.01）. Conclusion heroin dependent patients can recover body immune function, mucosal immune level gradually after methadone maintenance treatment, and curative effect is related to medicine dosage.

关 键 词：美沙酮维持 黏膜 唾液 免疫 

分 类 号：R749.64[医药卫生—神经病学与精神病学]