钌催化β-酮酸酯不对称氢化反应的研究进展  

Progress in Ruthenium-Catalyzed Asymmetric Hydrogenation of β-Keto Esters

作　　者：陈姝琪 杨文[1] 姚永祺 杨新 邓颖颍 杨定乔[1] Chen Shuqi;Yang Wen;Yao Yongqi;Yang Xin;Deng Yingying;Yang Dingqiao(Key Laboratory of Theoretical Chemistry of Environment,Ministry of Education,School of Chemistry and Environment,South China Normal University,Guangzhou 510006)

机构地区：[1]华南师范大学化学与环境学院教育部环境理论化学重点实验室,广州510006

出　　处：《有机化学》2018年第10期2534-2552,共19页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21172081;21372090);广东省自然科学基金重点(No.S2013020013091);广州市科技计划(No.201510010054)资助项目~~

摘　　要：钌催化β-酮酸酯不对称氢化反应是合成手性β-羟基酯的重要方法之一.综述了近十年来钌催化β-酮酸酯不对称氢化反应的研究进展,重点讨论了手性配体、底物结构、溶剂和添加剂等因素对均相不对称氢化反应的影响以及载体材料和助剂等因素对多相不对称氢化反应的影响.Ruthenium-catalyzed asymmetric hydrogenation of β-keto esters is one of the most effective methods for the synthesis of chiral β-hydroxy esters. The recent research progress in ruthenium-catalyzed asymmetric hydrogenation of β-keto esters is reviewed. Great attention was paid to the influences of chiral ligands, substrate structure, solvents and additives on the homogeneous asymmetric hydrogenation, as well as the influences of support materials and additives on the heterogeneous asymmetric hydrogenation.

关 键 词：钌催化 Β-酮酸酯 不对称氢化 研究进展 

分 类 号：O621.251[理学—有机化学]