脑胶质瘤中Id1与VEGF的表达及其与肿瘤血管生成的关系  

The relationships and angiogenesis among the expressions of inhibitor of differetiation/DNA banding factor(Id1) and vascular endothelial growth factor(VEGF)in gliomas

作　　者：张涛[1] 王辉[1] 杨晓文[1] ZHANG Tao;WANG Hui;YANG Xiao-wen(Department of Neurosurgery,Taihe Hospital of Shiyan,Hubei Province 442000,China)

机构地区：[1]湖北省十堰市太和医院神经外科,湖北十堰442000

出　　处：《解剖学研究》2018年第5期390-393,402,共5页Anatomy Research

摘　　要：目的研究分化抑制因子(Id1)与血管内皮生长因子(VEGF)在正常脑组织、低级别脑胶质瘤和高级别脑胶质瘤组织中的表达情况,探讨其在肿瘤发生及肿瘤血管生成中的作用。方法应用免疫组织化学SABC法分别检测正常脑组织、低级别脑胶质瘤和高级别脑胶质瘤组织中Id1和VEGF的蛋白表达;分析Id1表达水平与脑胶质瘤临床病理特征的关系以及Id1与VEGF表达水平的相关性。结果 Id1阳性表达率在正常脑组织、低级别脑胶质瘤和高级别脑胶质瘤组织中分别为0%、72.0%和90.9%,差异有统计学意义(P<0.01);VEGF在正常脑组织、低级别脑胶质瘤和高级别脑胶质瘤中的阳性率分别为25.0%、60.0%和81.8%,差异有统计学意义(P<0.05);并且Id1与VEGF的表达呈正相关(r=0.320,P<0.05)。结论 Id-1和VEGF的表达呈正相关,在胶质瘤血管生成过程中起协同作用;Id1的表达与胶质瘤病理分级密切相关,可作为抗肿瘤血管生成治疗的新靶点,也可作为胶质瘤的一种肿瘤标记物为其早期诊断提供帮助。Objective To investigate the role of Id1 and VEGF in human glioma,and analyse its relationship to the pathological grades and the angiogenesis of glioma. Methods The expressions of Id1 and VEGF were detected in 47 cases of humen gliomas and 8 specimens of normal brain tissue by immunohistochemical staining（SABC methods）. Results The positive rates of Id1 expression in thenormal brain tissue,the low grade gliomas group and high grade gliomas group were0%,72.0% and 90.9% respectively,Statistically significant differences（P〈0.01）;The positive rates of VEGF expression in thenormal brain tissue、the low grade gliomas group and high grade gliomas group were 25.0%,60.0% and 81.8% respectively,Statistically significant differences（P〈0.05）;Evermore,there was a close correlation between VEGF expression and Id1 expression（r=0.320,P〈0.025）. Conclusion The expressions of Id1 protein had positive correlation with the expression of VEGF protein in gliomas,Id1 and VEGF play a important synergistic effect in the angiogenesis of glioma.Id1 expression have close relation with the pathological grading of gliomas and it may be as targets of antiangiogenic therapy,Id1 also can be choosed as tumor tracer for glioma early diagnosis.

关 键 词：脑胶质瘤 肿瘤血管生成 分化抑制因子 血管内皮生长因子 免疫组织化学染色 

分 类 号：R739.41[医药卫生—肿瘤]