P300和MoCA评估丙戊酸钠治疗后癫痫患者认知功能的短期变化对比  

Comparative of short-term changes in cognitive function in patients with epilepsy treated with sodium valproate by P300 and MoCA

作　　者：余娟 袁良津[1] 王雷[1] YU Juan;YUAN Liangjin;WANG Lei(Department of Neurology,the Affiliated Anqing Hospital of Anhui Medical University,Anqing 246003,China)

机构地区：[1]安徽医科大学附属安庆医院神经内科,安徽安庆246003

出　　处：《中国实用神经疾病杂志》2018年第19期2109-2113,共5页Chinese Journal of Practical Nervous Diseases

摘　　要：目的应用P300和MoCA量表观察症状性癫痫患者接受单药丙戊酸钠治疗前后认知功能的改变。方法对30例首诊的拟行丙戊酸钠单药治疗的症状性癫痫患者(实验组)和30例正常健康体检者(对照组)分别进行事件相关电位P300、MoCA量表测定,并对实验组单药口服丙戊酸钠3个月后、6个月后再次进行P300、MoCA量表复查。结果治疗前实验组MoCA评分为(26.00±1.17)分,对照组为(28.60±1.33)分,实验组MoCA评分较对照组低,差异有统计学意义(P<0.05)。治疗前实验组P300潜伏期(424.03±45.98)ms,对照组P300潜伏期(319.83±12.70)ms,实验组P300潜伏期较对照组长,差异有统计学意义(P<0.05)。经丙戊酸钠单药治疗3个月后,实验组MoCA评分(26.40±1.17)分,与治疗前比较差异无统计学意义(P>0.05);实验组P300潜伏期为(397.87±42.87)ms,与治疗前比较差异有统计学意义(P<0.05)。经丙戊酸钠治疗6个月后,实验组MoCA评分为(27.33±1.03)分,与治疗前比较差异有统计学意义(P <0.01);实验组P300潜伏期为(367.50±33.80)ms,与治疗前比较差异有统计学意义(P<0.01)。结论症状性癫痫患者存在认知功能障碍,口服丙戊酸钠可改善认知功能,且P300潜伏期较MoCA量表能更早反映癫痫患者短期认知功能变化。Objective P300 and MoCA scales were used to observe changes in cognitive function in patients with symptomatic epilepsy before and after treatment with single agent sodium valproate. Methods The event related potentials P300 and MoCA were measured in 30 patients with symptomatic epilepsy （experimental group） and 30 normal healthy subjects （control group） who were treated with sodium valproate monotherapy for the first time.The experimental group was given a single drug oral sodium valproate for 3 months,and after 6 months,the P300 and MoCA scales were reviewed again. Results The MoCA score of the experimental group before treatment was （26.00±1.17）,and the MoCA score of the control group was （28.60±1.33）.The MoCA score of the experimental group before treatment was lower than that of the control group,and the difference was statistically significant （ P 〈0.05）.The P300 incubation period （424.03±45.98） ms in the experimental group and the P300 incubation period （319.83±12.70） ms in the control group before treatment.The P300 latency of the experimental group was longer than that of the control group,and the difference was statistically significant （ P 〈0.05）.After 3 months of treatment with sodium valproate monotherapy,the MoCA score （26.40±1.17） of the experimental group was not significantly different from that before treatment （ P 〉0.05）;the incubation period of the experimental group was （397.87±42.87） ms,The difference before treatment was statistically significant （ P 〈0.05）.After 6 months of treatment with sodium valproate,the MoCA score of the experimental group was （27.33±1.03）,which was statistically significant （ P 〈0.01）.The incubation period of the experimental group was （367.50±33.80） ms.The difference was statistically significant （ P 〈0.01）. Conclusion Patients with symptomatic epilepsy have cognitive dysfunction.Oral sodium valproate can improve cognitive function,and the P300 latency can reflect the short term

关 键 词：癫痫 P300 MOCA 认知功能 丙戊酸钠 

分 类 号：R742.1[医药卫生—神经病学与精神病学]