Evaluation of microvascular reactivity with laser Doppler flowmetry in chronic kidney disease  

作　　者：Levente Babos Zoltán Járai János Nemcsik 

机构地区：[1]Department of Family Medicine,Semmelweis University,1125 Budapest,Hungary [2]Department of Cardiology,St.Imre Teaching Hospital,1115 Budapest,Hungary

出　　处：《World Journal of Nephrology》2013年第3期77-83,共7页世界肾病学杂志（英文版）

摘　　要：Cardiovascular diseases are the major causes of mortality in patients with chronic kidney disease(CKD).The complex process of accelerated athero- and arteriosclerosis in CKD is associated with this phenomenon,where endothelial dysfunction(ED) is one of the initial steps. Hence, the early diagnosis of ED can potentially lead to early interventions which could result in a better outcome for these patients. Several methodologies have been developed for the diagnosis of ED. Laser Doppler flowmetry(LDF) enables us to study the microcirculation continuously in a non-invasive manner. In our review we would like to focus on different tests developed for LDF, like postocclusive reactive hyperaemia,local heating, iontophoresis, microdialysis or analysis of flowmotion. We would also like to summarize the available data in CKD with these methodologies to enlighten their perspectives in the clinical use on this patient population.Cardiovascular diseases are the major causes of mortality in patients with chronic kidney disease （CKD）. The complex process of accelerated athero- and arte-riosclerosis in CKD is associated with this phenomenon, where endothelial dysfunction （ED） is one of the initial steps. Hence, the early diagnosis of ED can potentially lead to early interventions which could result in a better outcome for these patients. Several methodologies have been developed for the diagnosis of ED. Laser Doppler flowmetry （LDF） enables us to study the mi-crocirculation continuously in a non-invasive manner. In our review we would like to focus on different tests developed for LDF, like postocclusive reactive hyperaemia, local heating, iontophoresis, microdialysis or analysis of fowmotion. We would also like to summarize the avail-able data in CKD with these methodologies to enlighten their perspectives in the clinical use on this patient population.

关 键 词：Chronic kidney disease Laser Doppler fowmetry Endothelial dysfunction IONTOPHORESIS Postoc clusive reactive hyperaemia Local heating MICRODIALYSIS Flowmotion 

分 类 号：R54[医药卫生—心血管疾病]