Pathogenesis of glomerular haematuria  

作　　者：Claudia Yuste Eduardo Gutierrez Angel Manuel Sevillano Alfonso Rubio-Navarro Juan Manuel Amaro-Villalobos Alberto Ortiz Jesus Egido Manuel Praga Juan Antonio Moreno 

机构地区：[1]Department of Nephrology,Gregorio Mara?on Hospital [2]Department of Nephrology [3]Renal,Vascular and Diabetes Research Lab,ⅡS-Fundación Jiménez Díaz, Autonoma University (UAM) [4]Renal,Vascular and Diabetes Research Lab,ⅡS-Fundación Jiménez Díaz,Autonoma University (UAM)

出　　处：《World Journal of Nephrology》2015年第2期185-195,共11页世界肾病学杂志（英文版）

基　　金：Supported by Grants from FIS (Programa Miguel Servet:CP10/00479,PI13/00802 and PI14/00883);Spanish Society of Nephrology to Moreno JA;Institute of Research Queen Sophia,FRIAT and ISCIII fund PI10/00072 to Egido J.

摘　　要：Haematuria was known as a benign hallmark of some glomerular diseases, but over the last decade, new evidences pointed its negative implications on kidneydisease progression. Cytotoxic effects of oxidative stress induced by hemoglobin, heme, or iron released from red blood cells may account for the tubular injury observed in human biopsy specimens. However, the precise mechanisms responsible for haematuria remain unclear. The presence of red blood cells （RBCs） with irregular contours and shape in the urine indicates RBCs egression from the glomerular capillary into the urinary space. Therefore glomerular haematuria may be a marker of glomerular filtration barrier dysfunction or damage. In this review we describe some key issues regarding epidemiology and pathogenesis of haematuric diseases as well as their renal morphological fndings.Haematuria was known as a benign hallmark of some glomerular diseases, but over the last decade, new evidences pointed its negative implications on kidney disease progression. Cytotoxic effects of oxidative stress induced by hemoglobin, heme, or iron released from red blood cells may account for the tubular injury observed in human biopsy specimens. However, the precise mechanisms responsible for haematuria remain unclear. The presence of red blood cells(RBCs) with irregular contours and shape in the urine indicates RBCs egression from the glomerular capillary into the urinary space. Therefore glomerular haematuria may be a marker of glomerular filtration barrier dysfunction or damage. In this review we describe some key issues regarding epidemiology and pathogenesis of haematuric diseases as well as their renal morphological findings.

关 键 词：HAEMATURIA PATHOGENESIS Glomerular filtration barrier Dysmorphic red blood cells Chronic kidney disease Microscopic haematuria 

分 类 号：R692[医药卫生—泌尿科学] R973.3[医药卫生—外科学]