Impact of pelvic radiotherapy on the female genital tract and fertility preservation measures  

作　　者：Liam C Welsh Alexandra Taylor 

机构地区：[1]Department of Gynaecology,Royal Marsden Hospital, London SW3 6JJ, United Kingdom

出　　处：《World Journal of Obstetrics and Gynecology》2014年第2期45-53,共9页世界妇产科杂志

摘　　要：Radiotherapy to the pelvis can have a major and deleterious impact on the female genital tract. Despite significant advances in the technical delivery of radical pelvic radiotherapy there remains no way to avoid delivering substantial radiation doses to the ovaries and uterus for patients undergoing treatment for gynaecological cancers. Due to improved cure rates from radical chemo-radiotherapy and social trends toward delayed childbirth many women treated for cervical cancer with radical chemo-radiotherapy will wish to attempt to preserve their fertility. Whilst there are now established and emerging techniques for preserving ovarian function and ovarian tissue, there remains the difficulty of the irradiated uterus which, even if pregnancy can be achieved, results in an increased risk for pregnancyrelated complications. Future developments may offer women in this difficult situation more and improved options for fertility preservation.Radiotherapy to the pelvis can have a major and del-eterious impact on the female genital tract. Despite significant advances in the technical delivery of radical pelvic radiotherapy there remains no way to avoid de-livering substantial radiation doses to the ovaries and uterus for patients undergoing treatment for gynaeco-logical cancers. Due to improved cure rates from radical chemo-radiotherapy and social trends toward delayed childbirth many women treated for cervical cancer with radical chemo-radiotherapy will wish to attempt to pre-serve their fertility. Whilst there are now established and emerging techniques for preserving ovarian func-tion and ovarian tissue, there remains the difficulty of the irradiated uterus which, even if pregnancy can be achieved, results in an increased risk for pregnancy-related complications. Future developments may offer women in this difficult situation more and improved op-tions for fertility preservation.

关 键 词：RADIOTHERAPY Cervical carcinoma Prema-ture menopause INFERTILITY Fertility preservation 

分 类 号：R683.3[医药卫生—骨科学]