卵巢高低级别浆液性腺癌组织中FBXW7和ENO1的表达和意义  

Study on the expression and meaning of FBXW7 and ENO1 in high and low grade serous ovarian adenocarcinoma tissue

作　　者：沈爱红[1] 李月红[3] 宿敬存 郑宏江 张军[5] Shen Aihong;Li Yuehong;Sun Jingcun;Zheng Hongjiang;Zhang Jura(Department of Obstetrics and Gynecology,Jizhong Energu Fengfeng Group Hospital,Handan 056200,China)

机构地区：[1]河北省邯郸市冀中能源峰峰集团总医院妇产科,056200 [2]河北省邯郸市冀中能源峰峰集团总医院病理科,056200 [3]河北医科大学第二医院病理科 [4]邯郸市第一医院介入科 [5]河北医科大学第四医院妇科

出　　处：《中国综合临床》2018年第6期496-502,共7页Clinical Medicine of China

基　　金：河北省财政厅河北省卫生计生委临床医学优秀人才培养和基础课题研究项目冀财社（[2017]46号）

摘　　要：目的 研究FBXW7和ENO1在卵巢不同级别浆液性腺癌的表达情况及意义.方法 收集2006年1月至2011年5月冀中能源峰峰集团总医院妇产科卵巢浆液性腺癌标本60例,应用免疫组化的方法研究FBXW7和ENO1在60例高低级别卵巢浆液性腺癌表达情况,并与相应正常组织进行对比,分析FBXW7和ENO1蛋白与卵巢高低级别浆液性腺癌的预后.结果 FBXW7在40例卵巢高级别腺癌中表达阳性为9例,表达阳性率为22.5％（9/40）,在15例正常输卵管中的表达阳性为10例,表达阳性率66.7％（10/15）,差异有统计学意义（P=0.003）.FBXW7在20例低级别腺癌表达阳性5例,阳性率25.0％（5/20）,在15例正常卵巢组织中的表达阳性9例,阳性率为60.0％（9/15）,差异有统计学意义（P=0.04）.ENO1蛋白在40例高级别腺癌中表达阳性27例,表达阳性率是67.5％（27/40）,在15例正常输卵管中的表达阳性5例,阳性率33.3％（5/15）,差异有统计学意义（P=0.024）.ENO1蛋白在20例低级别腺癌中有15例阳性表达,表达阳性率是75.0％（15/20）,15例正常卵巢组织中的4例阳性表达,阳性率26.7％（4/15）,差异有统计学意义（P=0.006）.在卵巢高级别腺癌中FBXW7低表达与ENO1高表达无相关性（P=0.199）,在卵巢低级别腺癌中FBXW7低表达与ENO1高表达有显著的相关性（r=-0.733,P〈0.001）.在低级别浆液性腺癌中FBXW7蛋白高表达组和低表达组比较,5年生存率分别为：44.4％与32.1％,差异无统计学意义（P=0.052）.在卵巢高级别浆液性腺癌中,高表达组和低表达组,5年生存率分别为：20.0％与7.7％,差异无统计学意义（P=0.097）.ENO1在卵巢低级别浆液性腺癌中,高表达组5年生存率是7.4％,低表达组5年生存率是50.0％（P=0.023）.在高级别浆液性腺癌中ENO1,高表达组与低表达组比较,5年生存率分别为：0与40.0％,差异有统计学意义（P=0.001）.结论 FBXW7在卵巢高低级别腺癌中呈现低表达,表明FBXW7�Objective To investigate the expression and significance of FBXW7 and ENO1 in ovarian serous adenocarcinoma of different grades. Methods Immunohistochemistry was used to study the expression of FBXW7 and ENO1 in 60 cases of ovarian serous adenocarcinoma. The relationship between FBXW7 and ENO1 proteins and the prognosis of ovarian serous adenocarcinoma was analyzed. Results The positive rate of FBXW7 expression was 22. 5% （ 9/40） in 40 cases of ovarian high grade adenocarcinoma and 10 cases in 15 cases of normal oviduct. The positive rate of FBXW7 expression was 66. 7% （ 10/15） ,and the difference was statistically significant （ P=0. 003） . The expression of FBXW7 in 20 cases of low grade adenocarcinoma was 5 cases,and the positive rate was 25. 0%（ 5/20） . In 15 cases of normal ovarian tissue,9 cases were positive,and the positive rate was 60. 0%（ 9/15） . The difference was statistically significant （ P=0. 04） . The expression of ENO1 protein was 27 in 40 cases of high grade adenocarcinoma,and the positive rate of expression was 67. 5%（ 27/40） . 5 cases were positive in 15 normal fallopian tubes, and the positive rate was 33. 3%（ 5/15 ） . The difference was statistically significant （ P = 0. 024 ） . The expression of ENO1 protein was 15 in 20 cases of low grade adenocarcinoma,and the positive rate of expression was 75. 0%（ 15/20） . In 15 cases of normal ovarian tissue,4 cases were positive, and the positive rate was 26. 7%（ 4/15 ） . The difference was statistically significant （ P=0. 006） . There was no correlation between the low expression of FBXW7 and the high expression of ENO1 in high grade ovarian adenocarcinoma （ P= 0. 199 ） , but there was a significant correlation between the low expression of FBXW7 and the high expression of ENO1 in low grade ovarian adenocarcinoma （ P〈0. 05） . In low grade serous adenocarcinoma,the 5-year survival rates were 44. 4% and 32. 1% respectively,with no significant difference （ P = 0. 052 ） . In ovarian high-grade

关 键 词：FBXW7 ENO1 卵巢低级别浆液性腺癌 卵巢高级别浆液性腺癌 免疫组化 

分 类 号：R737.31[医药卫生—肿瘤]