ER阳性乳腺癌中FOXM1和GRP78蛋白表达与临床病理因素及预后的相关性研究  

Expression of the Forkhead Transcription Factor FOXM1 is Associated with Tumor Grade and GRP78 Expression in ER-positive Breast cancer

作　　者：李海东[1] 赵四成 李季丹[1] 陈橼[2] 王健[2] 黄向华[2] 张一心[2] 郭燕[3] LI Haidong;ZHAO Sicheng;LI Jidan;CHEN Yuan;WANG Jian;HUANG Xianghua;ZHANG Yixin;GUO Yan(Department of General Surgery,Affiliated Nantong Maternal and Child Health Care Hospital,Nantong University,Jiangsu 226300;Department of General Surgery;Deparmtnet of Pathology,Affiliated Nantong Tumor Hospital,Nantong University)

机构地区：[1]南通市妇幼保健院普外科,江苏226018 [2]南通大学附属肿瘤医院乳腺外科 [3]南通大学附属肿瘤医院病理科

出　　处：《交通医学》2018年第5期419-423,共5页Medical Journal of Communications

基　　金：南通市青年医学重点人才基金(068);南通市指令性科技计划(YYZ15021;YYZ16029)

摘　　要：目的:检测ER阳性乳腺癌组织中叉头框M1(forkhead boxM1,FOXM1)及葡萄糖调节蛋白78(glucoseregulated protein of 78kDa,GRP78)的表达水平,探讨其与临床各参数及预后的关系。方法:应用免疫组化技术检测FOXM1、GRP78在60例ER阳性乳腺癌中的表达,分析两者表达量的相关性,与临床病理参数的相关性及其对患者预后的影响。结果:FOXM1和GRP78在ER阳性乳腺癌癌组织中高表达,两者的表达呈正相关性;患者的无复发生存期(recurrence-free survival,RFS)与脉管侵犯、FOXM1、GRP78、Ki67表达、HER2表达有关,GRP78和FOXM1高表达均是ER阳性乳腺癌患者RFS的影响因素。结论:通过本研究发现FOXM1和GRP78在ER阳性乳腺癌癌组织中高表达,两者均影响ER阳性乳腺癌患者5年RFS时间。Objective：To explore the expressions of Glucose-regulated protein of 78kDa （GRP78） and Forkhead boxM1 （FOXM1） protein in ER-positive breast cancer by immunohistochemistry technique, the relationship between their levels and clinical parameters as well as efficacy and prognosis was studied. Methods：The expressions of GRP78 and FOXM1 situation in the surgical specimens of ER-positive breast cancer of 60 cases were detected by IHC.The correlation of GRP78 and FOXM1 expressions and their effect on the prognosis of ER-positive breast cancer patient were analyzed. Results：The GRP78 and FOXM1 protein expression were over-expressed and positively correlated on the level of expression in ER-positive breast carcinoma tissue.Univariate Cox regression analysis showed that it was statistically significant between the patients of RFS in 5 years and vascular invasion, FOXM1, GRP78, Ki67 and HER-2 over-expressed. Kaplan- Meier survival curves and Log-rank test were used to analyze the 5-years of RFS time, showing that FOXM1 and GRP78 over-expressions were influential factors of efficacy respectivelyin ER-positive breast cancer tissue. Conclusions：It was found that FOXM1 and GRP78 were highly expressed in ER-positive breast cancer tissue, both of which affected the prognosis of ER-positive breast cancer patients.

关 键 词：ER阳性乳腺癌 葡萄糖调节蛋白78 叉头框M1 无复发生存期 

分 类 号：R737.9[医药卫生—肿瘤]