颅痛饮加味联合帕罗西汀治疗偏头痛伴焦虑状态临床观察  

Clinical Observation of Modified Lutong Yin Combined with Paroxetine for Migraine Accompanied by Anxiety Status

作　　者：黄祖秀 胡万华[1] 周荣[1] HUANG Zuxiu;HU Wanhua;ZHOU Rong

机构地区：[1]温州市中医院神经内科,浙江温州325000

出　　处：《新中医》2018年第11期67-70,共4页New Chinese Medicine

基　　金：浙江省中医药科技计划项目(2015ZA196)

摘　　要：目的:观察评价颅痛饮加味联合盐酸帕罗西汀治疗偏头痛伴焦虑状态的临床疗效。方法:选取偏头痛伴焦虑状态患者共78例,随机分为观察组和对照组,各39例。在研究过程中脱落7例,其中观察组3例,对照组4例,最终观察组36例,对照组35例。对照组使用西药盐酸帕罗西汀治疗,观察组在对照组基础上予中药颅痛饮加味治疗,4周为一疗程。采用焦虑自评量表(SAS)和汉密尔顿焦虑量表(HAMA)评定疗效。结果:观察组的总有效率为83.33%,显著高于对照组48.57%(P <0.05)。治疗前,2组发作频率、发作总时间、SAS评分、HAMA评分比较,差异无统计学意义(P> 0.05)。治疗后,2组发作频率、发作总时间、SAS评分、HAMA评分较治疗前显著降低(P <0.05);观察组发作频率、发作总时间、SAS评分、HAMA评分显著低于对照组(P <0.05)。治疗后,观察组每4周偏头痛发作频率减少值、发作总时间缩短值均优于对照组,差异具有统计学意义(P <0.05)。结论:对于偏头痛伴焦虑状态患者,予中药颅痛饮辨证加味联合西药盐酸帕罗西汀临床疗效要优于单纯西药盐酸帕罗西汀,且中西医结合治疗可显著改善患者的治疗依从性,有效地舒缓了患者的焦虑情绪。Objective： To observe the clinical effect of modified Lutong yin combined with paroxetine for migraine accompanied by anxiety status. Methods： Selected 78 cases of patients with migraine accompanied by anxiety status, and divided them into the observation group and the control group randomly, 39 cases in each group. During observation, a total of 7 cases dropped out, among which were 3 cases in the observation group and 4 cases in the control group, so finally there left 36 cases in the observation group and 35 cases in the control group. The control group received the simple application of western medicine paroxetine, while the observation group additionally received Chinese herbal medicine modified Lutong yin. One course of treatment lasted for 4 weeks. Evaluated the clinical effect via self-rating anxiety scale （SAS） and Hamilton anxiety scale （HAMA）. Results： The total effective rate was 83.33% in the observation group, being significantly higher than 48.57% in the control group （P 〈 0.05）. Before treatment, there were no significant differences being found when comparing the seizure frequency, total duration of seizure, scores of SAS and HAMA in-between both groups （P 〉 0.05）. After treatment, the seizure frequency, total duration of seizure, scores of SAS and HAMA in both groups were significantly lower than those before treatment （P 〈 0.05）; the seizure frequency, total duration of seizure, scores of SAS and HAMA in the observation group were significantly lower than those in the control group （P 〈 0.05）. After treatment, the reduction of seizure frequency and duration of seizure every 4 weeks in the observation group was respectively better than that in the control group, difference being significant （P 〈 0.05）. Conclusion： For patients with migraine accompanied by anxiety status, the clinical effect of Chinese herbal medicine based on syndrome differentiation combined with western medicine, namely modified Lutong yin combined with paroxetine, is better than t

关 键 词：偏头痛 焦虑 颅痛饮 帕罗西汀 焦虑自评量表(SAS) 汉密尔顿焦虑量表(HAMA) 

分 类 号：R747.2[医药卫生—神经病学与精神病学]