疣毒净制剂对高危型人乳头瘤病毒感染患者宫颈局部免疫细胞的影响  

Effects of Youdujing Preparation on Local Immune Cells in the Cervix of Patients with High-risk Human Papillomavirus Infection

作　　者：唐虹[1] 龙泳伶[2] 刘丽华[1] 孙琼洋[1] TANG Hong;LONG Yongling;LIU Lihua;SUN Qiongyang

机构地区：[1]广东省中医院,广东广州510120 [2]广州中医药大学,广东广州510006

出　　处：《新中医》2018年第11期135-138,共4页New Chinese Medicine

基　　金：广东省中医药局课题(20161099)

摘　　要：目的:通过检测高危型人乳头瘤病毒(HR-HPV)感染患者宫颈局部免疫细胞的数量,观察疣毒净制剂对宫颈局部免疫细胞的影响。方法:将70例HR-HPV感染患者根据是否接受疣毒净制剂治疗而分为治疗组和对照组各35例。治疗组以疣毒净外洗液、点涂霜治疗,治疗3个月经周期;对照组不用药,随访3月。观察HR-HPV的转阴情况与宫颈病变程度,测定宫颈活检组织中基底层及上皮层中的CD4^+、CD8^+细胞计数,计算CD4^+/CD8^+比值。结果:3月后,治疗组HR-HPV转阴率为74.3%,对照组HR-HPV转阴率为14.3%,2组比较,差异有统计学意义(P <0.01)。治疗组好转率为88.6%,对照组好转率为45.7%,2组比较,差异有统计学意义(P <0.05)。治疗组宫颈组织CD4^+细胞计数值较治疗前上升,差异有统计学意义(P <0.05),CD8^+细胞计数值与治疗前比较,差异无统计学意义(P> 0.05)。对照组CD8^+细胞计数值与随访前比较有所增加,差异有统计学意义(P <0.05),CD4^+细胞计数值与随访前比较稍有增高,但差异无统计学意义(P> 0.05),治疗组宫颈组织CD4^+细胞计数值高于对照组,CD8^+细胞计数值低于对照组,差异均有统计学意义(P <0.05)。治疗组宫颈组织CD4^+/CD8^+比值≥1的病例数多于对照组,差异有统计学意义(P <0.01)。结论:采用疣毒净制剂治疗宫颈HPV感染疗效明显,可有效提高HPV转阴率和宫颈病变的组织学疗效,作用机制可能与增强机体的细胞免疫功能有关,是防治HPV感染有效的中医药疗法。Objective： To observed the effect of Youdujing preparation on local immune cells in the cervix by measuring the number of local immune cells in the cervix of patients with high-risk human papillomavirus （HR-HPV） infection. Methods： Divided 70 cases of patients with HR-HPV infection into the treatment group and the control group according to whether they were treated with Youdujing preparation, 35 cases in each group. The treatment group was treated with Youdujing external lotion and cream, and treated for three menstrual cycles. The control group did not take medicine and were followed up for three months. Observed the condition of HR-HPV becoming negative and the degree of cervical lesions： measured the number of CD4^＋ and CD8^＋ cells in basal layer and epithelial layer of cervical biopsy tissue; calculated the ratio of CD4^＋ to CD8^＋. Results： After three months, the negative conversion rate of HR-HPV was 74.3% in the treatment group and 14.3% in the control group, the difference being significant （P 〈 0.01）. The improvement rate was 88.6% in the treatment group and 45.7% in the control group, the difference being significant （P 〈 0.05）. CD4^＋ cell count in cervical tissue in the treatment group was increased when compared with that before treatment, the difference being significant （P 〈 0.05）; after treatment, there was no significant difference being found in the comparison of CD8^＋ cell count when compared with that before treatment （P 〉 0.05）. CD8^＋ cell count in the control group was increased when compared with that before the follow-up, the difference beingsignificant （P 〈 0.05）; CD4^＋ cell count was slightly increased when compared with that before the follow-up, there being no significance in the difference （P 〉 0.05）. CD4^＋ cell count in the treatment group was higher than that in the control group, while CD8^＋ cell count was lower, differences being significant （P 〈 0.05）. The number of cases of patients （CD4^＋/CD8^＋≥1�

关 键 词：高危型人乳头瘤病毒(HR-HPV) HPV感染 疣毒净 免疫T淋巴细胞 

分 类 号：R737.33[医药卫生—肿瘤]