黄芩苷口腔缓释膜辅助治疗慢性牙周炎临床观察  

Clinical Observation on Baicalin Oral Sustained Release Membrane in the Adjuvant Treatment for Chronic Periodontitis

作　　者：卢惠冰[1] 徐雄均[2] 杨伟湘 王忠献[1] LU Huibing;XU Xiongjun;YANG Weixiang;WANG Zhongxian

机构地区：[1]广州中医药大学第一附属医院口腔科,广东广州510045 [2]中山大学附属三院口腔科,广东广州510630

出　　处：《新中医》2018年第11期156-159,共4页New Chinese Medicine

基　　金：广东省中医药局课题(20172047)

摘　　要：目的:观察黄芩苷口腔缓释膜辅助治疗慢性牙周炎的临床疗效。方法:178例患者,取每1例患者口内牙周探诊深度及探诊出血程度相近的牙随机分为2组,即试验牙组和对照牙组,每组296颗。2组均经过基础牙周治疗,试验牙组在基础治疗上使用双氧水加生理盐水冲洗配合自制黄芩苷口腔缓释膜治疗,对照牙组在基础治疗上仅用双氧水加生理盐水冲洗。观察并比较2组牙周探诊深度(PD)、龈沟出血指数(SBI)、附着丧失(AL)及临床疗效。结果:治疗前,2组PD、SBI、AL比较,差异均无统计学意义(P> 0.05)。与治疗前比较,2组治疗1月后及3月后的PD、SBI、AL均少于治疗前,差异均有统计学意义(P <0.05)。治疗1月后及3月后,试验牙组的PD、SBI均少于对照牙组,2组比较差异有统计学意义(P <0.05)。治疗完成1个月及3个月后,试验牙组的显效率高于对照牙组,差异有统计学意义(P <0.05);2组的总有效率比较,差异无统计学意义(P>0.05)。结论:黄芩苷口腔缓释膜有助于牙周组织的炎症恢复,对于牙周组织的再生修复效果并不显著。Objective： To observe the clinical effect of baicalin oral sustained release membrane in the adjuvant treatment for chronic periodontitis. Methods. Selected 178 cases of patients, and divided the teeth of each patient, whose periodontal depth and bleeding on probing were similar, into two groups randomly, namely the experimental teeth group and the controlled teeth group, 296 teeth in each group. The two groups received basic periodontal treatment. The experimental teeth group was additionally treated with hydrogen peroxide plus saline irrigation combined with self-made baicalin oral sustained release membrane. The controlled teeth group was additionally treated with hydrogen peroxide plus saline irrigation. Observed and compared the periodontal depth（PD）, sulcus bleeding index（SBI）, attachment loss （AL） and clinical effect in the two groups. Results： Before treatment, there was no significant difference being found in the comparisons of PD, SBI and AL in the two groups（P 〉 0.05）. Compared with those before treatment, PD, SBI and AL after one month of treatment and three months of treatment in the two groups were decreased, differences being significant（P 〈 0.05）. After one month of treatment and three months of treatment, PD and SBI in the experimental teeth group were lower than those in the controlled teeth group, the difference being significant（P 〈 0.05）. After one month of treatment and three months of treatment, the marked effective rate in the experimental teeth group was higher than that in the controlled teeth group, the difference being significant（P 〈 0.05）. There was no significant difference being found in the comparison of the total effective rate in the two groups （P 〉 0.05）. Conclusion： Baicalin oral sustained release membrane is helpful for the recovery of periodontal inflammation and has less siqnificant effect on the regeneration and repair of periodontal tissue.

关 键 词：牙周炎 黄芩苷 口腔缓释膜 牙周探诊深度(PD) 龈沟出血指数(SBI) 附着丧失(AL) 

分 类 号：R781.42[医药卫生—口腔医学]