糖皮质激素滴眼液局部频点联合降眼压滴眼液治疗白内障超声乳化术后角膜内皮水肿的临床疗效观察  

The clinical efficacy of frequent use of glucocorticoid eye drops combined with ocular hypotensive eyedrops in treating corneal endothelial edema after phacoemulsification

作　　者：刘家佳 温跃春 柯根杰 季青山 董怡然 LIU Jia-jia;WEN Yue-ehun;KE Gen-jie;JI Qing-shan;DONG Yi-ran(Department of Ophthalmology,The First Affiliated Hospital of University of Scienee and Technology of China,Hefei,230001,China)

机构地区：[1]中国科学技术大学附属第一医院眼科,230001

出　　处：《实用防盲技术》2018年第4期140-142,145,共4页Journal of Practical Preventing Blind

基　　金：安徽省自然科学基金青年项目(AHNSF1408085QH159)

摘　　要：目的研究糖皮质激素滴眼液频点联合降眼压滴眼液控制目标眼压在治疗白内障超声乳化术后角膜内皮水肿的临床疗效方法选取2015年1月-2017年12月于中国科学技术大学附属第一医院眼科行白内障超声乳化吸除术后角膜内皮水肿的患者80例80眼,随机分为观察组和对照组,各40例40眼。对照组患者行糖皮质激素滴眼液、非甾体类抗炎滴眼液及托吡卡胺滴眼液滴眼常规频次点眼,眼压不超过21mmHg不做特殊处理;观察组患者使用非甾体类抗炎滴眼液、托吡卡胺滴眼液常规频次点眼,糖皮质激素滴眼液频点,同时联合降眼压滴眼液控制术后眼压范围在9-12mmHg范围。术后通过裂隙灯检查,观察记录两组患者用药后1天、3天、7天、15天的角膜水肿消退情况,比较两组角膜水肿消退时间。结果观察组患者用药后将眼压控制在9-12mmHg,观察组患者术后角膜水肿消退较对照组快、视力恢复时间较对照组明显缩短,两组比较差异具有统计学意义(P<0.05)。结论糖皮质激素滴眼液局部频点联合降眼压滴眼液以控制目标眼压在治疗白内障超声乳化吸除术后角膜内皮水肿的疗效肯定。Objctive To study the clinical efficacy of frequent use of glucocorticoid eye drops combined with ocular hypotensive eyedrops in treating corneal endothelial edema after phacoemulsification. Methods 80 eyes of 80 patients suffering corneal endothelial edema after receiving phacoemulsification from Jan, 2015 to Dec, 2017 were selected and classified into observation group and control group randomly, with 40 patients （40 eyes） for each group. The patients of the control group treated with glucocorticoid eyedrops, nonsteroidal anti-inflammatory eyedrops and tropicamide eyedrops, and special treatment was not done to those whose intraocular pressure did not exceed 21mmHg; after frequent use of glucocorticoid eyedrops, and eye dropping with nonsteroidal anti-inflammatory eye drops and tropicamide eye drops and combined intraocnlar pressure reduction eye dropcontrology, the patients of the observation group had an intraocular pressure range of 9-12mmHg. Cornealedema reductioncondition of the two groups of patients at the 1st, 3rd, 7th and 15th day after drug use were observed, and corneal edema regression time of the two groups of patients were compared. Results Intraocular pressure of the patients of the observation group after drug use was controlled at 9-12mmHg, postoperative corneal edema regression of whom was faster than that of the control group, visual recovery time of who was obviously shorter than that of the control group, comparative differences between the two groups were statistically significant, （P〈0.05）. Conclusions Target intraocular pressure control by local frequent dropping of glucocorticoid eye drops combined with intraocular pressure reduction eye drops has definite curative effect in treating corneal endothelial edema after phacoemulsification.

关 键 词：白内障超声乳化吸除 角膜内皮水肿 糖皮质激素滴眼液 降眼压 

分 类 号：R779.66[医药卫生—眼科]