逍遥丸治疗盆腔炎疗效及对患者SOD、MDA、白介素族水平影响的研究  

Effect of Xiaoyao pill on SOD MDA and interleukin-family index in patients with pelvic inflammation

作　　者：段杨平[1] 田兆华[1] 李梅[1] 贾晓慧[1] 苗凤台 Duan Yangping;Tian Zhaohua;Li Mei(Department of Obstetrics and Gynecology,Zhengzhou People＇s Hospital in Henan Province,Zhengzhou 45000)

机构地区：[1]河南省郑州人民医院妇产科,郑州450000

出　　处：《陕西中医》2018年第12期1749-1752,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：河南省中医管理局科研项目(2016ZY2097)

摘　　要：目的:分析盆腔炎患者应用逍遥丸治疗临床效果及对血清超氧化物歧化酶(SOD)、丙二醛(MDA)及白介素族等指标的影响。方法:选取某院收治盆腔炎患者共84例,采用随机数字分配法将患者分为试验组42例、对照组42例。对照组患者实施常规治疗;试验组患者在此基础上增用逍遥丸,1袋/次,2次/d,连续服用2周为1个疗程。治疗前后采集两组患者肘部静脉血,空腹状态采集10ml,选取一部分装入EDTA抗凝采血管,3000r/min,离心10min,离心结束后选取上清液,放置于-80℃冰箱内保存,以备使用。所选对象的血清SOD、MDA水平检测选用双抗体夹心法。结果:试验组经过治疗后29例患者痊愈(69.0%),11例有效(26.2%),临床治疗有效率95.2%,对照组治疗后17例痊愈(40.5%),15例有效(35.7%),临床有效率78.5%,试验组明显高于对照组,差异具有统计学意义(P<0.05)。试验组患者治疗前SOD数值为(113.2±15.1)U/L,治疗后上升至(251.5±20.1)U/L,MDA治疗前为(13.3±2.0)mmol/ml,治疗后下降至(7.5±2.0)mmol/ml,IL-4治疗前(43.1±6.1)pg/ml,治疗后(50.2±7.4)pg/ml,IL-8治疗前(90.5±12.0)pg/ml,治疗后(70.5±10.7)pg/ml,对照组患者治疗前SOD数值为(113.3±16.1)U/L,治疗后上升至(151.5±12.9)U/L,MDA治疗前为(13.5±2.1)mmol/ml,治疗后下降至(10.5±2.0)mmol/ml,IL-4治疗前(43.5±6.0)pg/ml,治疗后(60.5±8.1)pg/ml,IL-8治疗前(90.4±12.2)pg/ml,治疗后(84.5±10.0)pg/ml,两组患者各项指标均出现改善,但试验组改善情况优于对照组(P<0.05),与其他报道中数据吻合。治疗过程中试验组患者偶见皮疹、食欲减退、头晕恶心等不良症状,但发生概率小于对照组,可见逍遥丸治疗盆腔炎临床效果肯定,且不良反应轻微,与其他报道结果吻合。结论:盆腔炎患者临床治疗中应用逍遥丸可显著降低MDA、白介素族中IL-8水平,对SOD及白介素族IL-4有明显提升作用。Objective： To analyze the clinical effects of Xiaoyao pill in patients with pelvic inflammatory disease and its effects on serum superoxide dismutase （SOD）, malondialdehyde （MDA） and interleukins. Methods： A total of 84 patients with pelvic inflammatory disease were enrolled in hospital. The patients were divided into experimental group （42 cases） and control group （42 cases） by random number distribution. The patients in the control group were given routine treatment. The patients in the experimental group were given Xiaoyao pills on the basis of this, 1 bag/time, taking 2 times a day, and taking 2 weeks for a course of treatment. Elbow venous blood was collected from both groups before and after treatment. 10 ml was collected in the fasting state. A part of the EDTA anticoagulant blood collection tube was selected and centrifuged at 3000 r/min for 10 min. After the end of the centrifugation, the supernatant was selected and stored in a -80 °C refrigerator. Serum SOD and MDA levels were selected for the selected subjects using the double antibody sandwich method. Results： After treatment in the experimental group, 29 patients were cured （69.0%）, 11 patients were effective （26.2%）, and the clinical treatment efficiency was 95.2%. After treatment in the control group, 17 patients recovered （40.5%） and 15 patients were effective （35.7%）. The clinical effective rate was 78.5%. The experimental group was significantly higher than the control group, and the difference was statistically significant （ P 〈0.05）. The preoperative SOD value of the experimental group was （113.2±15.1） U/L, and it increased to （251.5±20.1） U/L, before treatment with MDA （13.3±2.0） mmol/ml, decreased to （7.5±2.0） mmol/ml after treatment, （43.1±6.1） pg/ml before IL-4 treatment, after treatment （50.2±7.4） pg / ml, IL-8 before treatment （90.5 ± 12.0） pg / ml, after treatment （70.5±10.7） pg / ml, control group patients before treatment SOD value （113.3±16.1）

关 键 词：盆腔炎性疾病/中西医结合疗法 @逍遥丸 疗效比较研究 

分 类 号：R743.31[医药卫生—神经病学与精神病学]