预防性脑照射治疗局部晚期非小细胞肺癌的临床效果  

Clinical effect of prophylactic brain irradiation in the treatment of locally advanced non-small cell lung cancer

作　　者：罗志强[1] 李俊玉[1] 刘珺[1] LUO Zhi-qiang;LI Jun-yu;LIU Jun(Department of Oncology and Radiotherapy,Jiangxi Cancer Hospital,Nanehang 330029,China)

机构地区：[1]江西省肿瘤医院肿瘤放疗科,江西南昌330029

出　　处：《中国当代医药》2018年第32期56-58,共3页China Modern Medicine

基　　金：江西省卫生计生委科技计划项目(20155498)

摘　　要：目的探讨预防性脑照射治疗局部晚期非小细胞肺癌的临床效果。方法选取2014年3月~2016年3月我院收治的80例局部晚期非小细胞肺癌患者作为研究对象,以随机数字表法将其分为观察组(40例)和对照组(40例)。对照组患者予以常规放、化疗治疗,观察组患者在上述基础上加用预防性脑照射治疗。比较两组患者的临床疗效、生存情况及治疗前后的生活质量评分。结果观察组患者的缓解率(RR)为77.5%(31/40),疾病控制率(DCR)为97.5%(39/40),均显著高于对照组的40.0%(16/40)、72.5%(29/40),差异有统计学意义(P<0.05);观察组患者的中位生存时间长于对照组,1年生存率和2年生存率均高于对照组,差异有统计学意义(P<0.05);两组患者治疗后的QLQ-C30评分均高于治疗前,且观察组患者治疗后的QLQ-C30评分显著高于对照组,差异有统计学意义(P<0.05)。结论预防性脑照射治疗局部晚期非小细胞肺癌可延长患者生存期,提高生活质量,疗效显著,值得在临床上推广应用。Objective To explore the clinical effect of prophylactic brain irradiation in the treatment of locally advanced non-small cell lung cancer. Methods A total of 80 patients with locally advanced non-small cell lung cancer admitted in our hospital from March 2014 to March 2016 were selected as subjects and were randomly divided into observation group（40 cases） and control group（40 cases）. The control group was treated with conventional radiotherapy and chemotherapy, and the observation group was treated with preventive brain radiation on the basis of the above. The clinical efficacy, survival and quality of life before and after treatment were compared between the two groups. Results The remission rate（RR） of the observation group was 77.5%（31/40）, and the DCR was 97.5%（39/40）, which were significantly higher than those in the control group of 40.0%（16/40） and 72.5%（29/40）, the differences were statistically significant（P〈0.05）. The median survival time in the observation group was longer than that in the control group, the 1-year survival rate and the 2-year survival rate were significantly higher than those in the control group, the differences were statistically significant（P〈0.05）. The QLQ-C30 score of the two groups after treatment were higher than those before treatment, and the QLQ-C30 score of the observation group was significantly higher than that of the control group after treatment, the differences were statistically significant（P〈0.05）. Conclusion Prophylactic brain irradiation for locally advanced non-small cell lung cancer can prolong the survival time and improve the quality of life. The curative effect is remarkable, and it is worth popularizing in clinical application.

关 键 词：非小细胞肺癌 预防性脑照射 脑转移 生存期 

分 类 号：R734.2[医药卫生—肿瘤]