^(89)SrCl_2治疗多发性骨转移92例对患者疼痛、体能状况及血常规影响研究  

The effect of ^(89)SrCl_2 on pain,physical status and blood routine in 92 patients with bone metastases

作　　者：彭艳艳[1] 李红玲[1] 张旭霞[1] 张玲芳[1] 杨静[1] 刘乐[1] 邰宵辉 Peng Yanyan;Li Hongling;Zhang Xuxia(Gansu Provincial Hospital（Lanzhou 73000)

机构地区：[1]甘肃省人民医院肿瘤内科,兰州730000

出　　处：《陕西医学杂志》2018年第12期1556-1558,共3页Shaanxi Medical Journal

基　　金：甘肃省自然科学基金资助项目(17JR5RA037)

摘　　要：目的:分析89SrCl2治疗对有化疗史及无化疗史的多发性骨转移癌患者疼痛、体能状况及血常规的影响。方法:将92例有89SrCl2治疗史的多发性骨转移癌患者根据有无化疗史分为有化疗史组及无化疗史组。对比两组患者89SrCl2治疗前后的疼痛评分及体能状况、治疗后骨髓抑制程度及时间。结果:有化疗史及无化疗组的患者分别使用89SrCl2后疼痛及体能状况均得到改善,前后对比差异具有统计学意义(P<0.05);有化疗史组及无化疗史组患者疼痛缓解率分别为82.0%(41/50例)、81.0%(34/42例)。有化疗史组较无化疗史使用89SrCl2后发生Ⅲ度及以上骨髓抑制的比例增加,抑制时间相对延长,差异无统计学意义(P>0.05)。结论:89SrCl2治疗对于多发性骨转移癌患者在减轻疼痛及改善体能状况方面安全、有效;对于有多疗程化疗史的患者使用89SrCl2后发生骨髓抑制的风险增加,故应慎重选择治疗时机。Objective：Analyze the effects of ^89SrCl2 on the pain, physical status and blood routine of patients with multiple bone metastases with chemotherapy history group and no chemotherapy history group. Methods：92 patients with multiple bone metastases were divided into chemotherapy history group and no chemotherapy history group.The NRS、KPS and Blood routinewere compared between the 2 groups before and after the treatment of ^89SrCl2 . Results： The NRS and KPS of the 2 groups were observed before and after treatment, and the degree and time of bone marrow suppression after treatment were observed. The pain and physical condition of patients with chemotherapy and without chemotherapy after used ^89SrCl2 were improved, with statistical significance after comparing the difference （ P 〈0.05）; Chemotherapy history group and no chemotherapy history group the pain remission rate was 82% （41/50 cases） and 81% （34 /42 cases）. In the group with history of chemotherapy, the proportion of myelosuppression with III degree and above increased after the use of ^89SrCl2 in the group without chemotherapy. The inhibition time was longer, but the difference was not statistically significant （ P 〉0.05）. Conclusion： ^89SrCl2 for multiple bone metastasis in the patients to relieve pain and improve the physical condition of safe and effective; for a course of chemotherapy in patients with a history of ^89SrCl2 , so the treatment should be careful.

关 键 词：骨肿瘤/治疗 锶放射性同位素/治疗应用 癌性疼痛/治疗 体质 肿廇转移 

分 类 号：R738.1[医药卫生—肿瘤]