CyclinA2基因多态性与肝细胞肝癌易感性的关系  

Relationship between Polymorphism of CyclinA2 Gene and Susceptibility to Hepatocellular Carcinoma

作　　者：袁国辉 戴超 吴兆平[1] 陈伟力[1] 梅保华[1] YUAN Guo-hui;DAI Chao;WU Zhao-ping;CHEN Wei-li;MEI Bao-hua(Department of Hepatobiliary Surgery,the First People＇s Hospital of Jiujiang,Jiujiang 332000,Jiangxi,China)

机构地区：[1]九江市第一人民医院肝胆外科,江西九江332000

出　　处：《医学信息》2018年第22期77-80,共4页Journal of Medical Information

摘　　要：目的探讨CyclinA2启动子区单核苷酸多态性与肝细胞肝癌发病风险的关系。方法选取2012年10月～2017年9月在九江市第一人民医院确诊的原发性肝细胞肝癌患者180例,同时选择行体检的健康志愿者180例作为对照组。分别采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法对cyclinA2基因的rs769236位点进行多态性检测,比较不同基因型与原发性肝细胞癌发病风险的关系。结果 rs769236等位基因A(GA+AA)携带者患原发性肝细胞癌的风险显著高于rs769236GG野生基因型的个体(校正OR=1.825,95%CI=1.133-2.940)。结论 CyclinA2基因rs769236(G/A)位点A变异可能会增加原发性肝细胞癌的发病风险。Objective To investigate the relationship between cyclinA2 promoter single nucleotide polymorphism （SNP） and the risk of hepatocellular carcinoma.Methods From October 2012 to September 2017, 180 patients with primary hepatocellular carcinoma diagnosed in the First People＇s Hospital of Jiujiang city were selected,at the same time, 180 healthy volunteers were selected as control group.Polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） was used to detect the rs769236 locus of cyclinA2 gene and compare the relationship between different genotypes and the risk of primary hepatocellular carcinoma.Results The risk of rs769236 allele A （GA＋AA） carriers with primary hepatocellular carcinoma was significantly higher than that of the rs769236GG wild genotype （corrected 0R=1.825, 95% CI=1.133-2.940）. Conclusion CyclinA2 gene rs769236 （G/A） site A mutation may increase the risk of primary hepatocellular carcinoma.

关 键 词：肝细胞肝癌 CyclinA2 单核苷酸多态性 

分 类 号：R735.7[医药卫生—肿瘤]