卵巢癌患者外周血免疫指标及炎性因子的检测及临床意义  

Detection of peripheral blood immune indexes and inflammatory factors of patients with ovarian cancer and their clinical significance

作　　者：崔彭华[1] 李志艳 张玉娟[1] 刘莉[1] CUI Penghua;LI Zhiyan;ZHANG Yujuan;LIU Li(Affiliated Hospital of Chengde Medical College,Chengde,Hebei Province,06700)

机构地区：[1]承德医学院附属医院,067000

出　　处：《中国计划生育学杂志》2018年第11期1098-1101,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨卵巢癌患者外周血免疫指标及炎性因子水平的变化及临床意义。方法:选择本院妇科收治的卵巢癌患者43例(恶性组),另选卵巢良性肿瘤患者55例(良性组)和健康妇女50例(对照组)。测定各组及不同临床分期Th1、Th2、Th1/Th2、调节性T淋巴细胞(Treg)及炎症因子包括白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)及干扰素(INF?γ)水平变化。结果:良性组与对照组Th1、Th2、Th1/Th2、Treg、IL-2、INF?γ、IL-6及IL?10变化不显著(P>0.05);恶性组Th1、Th1/Th2、IL-2及INF?γ水平较对照组及良性组显著降低,而Th2、Treg、IL-6及IL-10水平较对照组及良性组增加(P<0.05);卵巢癌Ⅲ期?Ⅳ期Th1、Th1/Th2、IL-2及INF?γ水平较Ⅰ期?Ⅱ期降低,而Th2、Treg、IL-6及IL-10水平较Ⅰ期?Ⅱ期增加(P<0.05)。结论:卵巢癌患者的外周血存在免疫功能紊乱且炎症反应较为剧烈,该指标对临床有参考意义。Objective To explore the changes of immune indexes and inflammatory factors in peripheral blood of patients with ovarian cancer, and to study their clinical significance. Methods： 43 women with ovarian cancer in affiliated hospital of Chengde medical college were selected into malignant group, 55 women with benign ovarian tumors were selected into benign group, and 50 healthy women were selected into control group. The changes of Th1, Th2, Th1/Th2, regulatory T lymphocyte （Treg）, and inflammatory factors, such as interleukin 2 （IL 2）, interleukin 6 （IL 6）, interleukin 10 （IL 10） and INF gamma（INF γ）of all women during different clinical stages or in each group were measured. Results： There were no significant in changes of Th1, Th2, Th1/Th2, Treg, IL 2, INF γ, IL 6 and IL 10 of women between benign group and malignant group （ P 〉0.05）. The levels of Th1, Th1/Th2, IL 2 and INF γ of women in malignant group were significant lower than those of women in control group and in benign group, while the levels of Th2, Treg, IL 6 and IL 10 of women in malignant group were significant higher than those of women in control group and in benign group（ P 〈0.05）. The levels of Th1, Th1/Th2, IL 2 and INF γ of women with stage III IV of ovarian cancer were significant lower than those of women with phase I II of ovarian cancer, while the levels of Th2, Treg, IL 6 and IL 10 of women with stage III IV of ovarian cancer were significant higher than those of women with phase I II of ovarian cancer （ P 〈0.05）. Conclusion： The immune dysfunction and inflammatory reaction in peripheral blood of women with ovarian cancer are more severe, so they have some clinical significance.

关 键 词：卵巢癌 免疫指标 炎性因子 

分 类 号：R737.31[医药卫生—肿瘤] R730.43[医药卫生—临床医学]