艾司西酞普兰与帕罗西汀治疗老年性抑郁症效果比较研究  

A comparative study of escitalopram and paroxetine in the treatment of senile depression

作　　者：马建英[1] 杨勇 杨轩皓 Ma Jianying;Yang Yong;Yang Xuanhao(Department of Psychiatry,Rehabilitation Hospital,Lianyungang City,Jiangsu Province,Lianyungang,Jiangsu,222003,China)

机构地区：[1]江苏省连云港市康复医院精神科,江苏连云港222003

出　　处：《当代医学》2018年第32期118-120,共3页Contemporary Medicine

摘　　要：目的分析艾司西酞普兰与帕罗西汀治疗老年性抑郁症效果。方法选择2016年5月～2017年11月本院收治的60例老年抑郁症患者为研究对象。将其分为艾司西酞普组以及帕罗西汀组,每组30例。分别使用上述药物治疗疾病,分析结果。结果帕罗西汀组治疗有效率为93.33%,艾司西酞普兰组为90.00%。两组治疗效果比较差异无统计学意义。和治疗前相比,治疗后患者的HAMD分数明显降低(P<0.05)。治疗2周后,艾司西酞普兰组的分数明显比帕罗西汀组低(P<0.05)。通过对比分析两组,差异无统计学意义。治疗前,两组的TESS分数差异无统计学意义。治疗后2周,艾司西酞普兰组比帕罗西汀组的TESS分数更低(P<0.05)。治疗第4、8周的分数差异无统计学意义。治疗后,复查病患肝脏以及肾脏功能、心电图功能后,患者无异常。结论对于老年性抑郁症疾病,使用艾司西酞普兰与帕罗西汀均能取得一定效果,相较而言,艾司西酞普兰治疗效果更好,不良反应少,值得进一步在临床中推广使用。Objective To analyze the efficacy of escitalopram and paroxetine in the treatment of senile depressive disorder. Methods Sixty elderly patients with depression who were admitted to our hospital from May 2016 to November 2017 were selected as the study subjects. They were divided into escitalopram group and paroxetine group, 30 cases in each group. The above drugs were used to treat the disease and the results were analyzed. Results The effective rate was 93.33% in the paroxetine group and 90.00% in the escitalopram group. There was no significant difference in treatment effect between the two groups. Compared with before treatment, the HAMD score of the patients after treatment was significantly lower （P〈 0.05）. After 2 weeks of treatment, the score of escitalopram group was significantly lower than that of paroxetine group（P〈 0.05）. There was no significant difference between the 4 and 6 groups. Before treatment, there was no significant difference in TESS scores between the two groups. Twoweeks after treatment, escitalopram group BIPA The TESS score of the roxistin group was lower（P〈0.05）. There was no significant difference between the 4th and 8th week treatment scores. After the treatment, the patient＇s liver and kidney function and electrocardiogram function were not abnormal. Conclusion For senile depressive disorders, the use of escitalopram and paroxetine can achieve certain results. Compared with escitalopram, escitalopram is more effective and has fewer adverse reactions. It is worthy of further promotion in clinical practice.

关 键 词：艾司西酞普兰 帕罗西汀 老年性抑郁症 安全性 

分 类 号：R749.4[医药卫生—神经病学与精神病学]