肠炎Ⅰ号方治疗大肠湿热型溃疡性结肠炎疗效观察  

Clinical Efficacy of Enteritis No.1 Prescription in Treatment of Ulcerative Colitis of Large Intestine Damp-Heat Type

作　　者：杜骏 王建民[2] 唐冉[2] 唐昆[2] 方笑丽 孙杭 DU Jun;WANG Jian-min;TANG Ran;TANG Kun;FANG Xiao-li;SUN Hang(Graduate School of Anhui University of Chinese Medicine,Anhui Hefei 230038,China;Department of Anus and Intestine Surgery,The First Affiliated Hospital of Anhui University of Chinese Medicine,Anhui Hefei 230031,China)

机构地区：[1]安徽中医药大学研究生院,安徽合肥230038 [2]安徽中医药大学第一附属医院肛肠外科,安徽合肥230031

出　　处：《安徽中医药大学学报》2018年第6期28-31,共4页Journal of Anhui University of Chinese Medicine

基　　金：安徽省科技攻关项目(1501041151)

摘　　要：目的观察肠炎Ⅰ号方治疗大肠湿热型溃疡性结肠炎(ulcerative colitis,UC)的临床疗效及其对血清炎性因子含量的影响。方法将60例大肠湿热型UC患者分为对照组和治疗组,每组30例,对照组患者给予美沙拉嗪栓1.0g塞肛,治疗组患者给予肠炎Ⅰ号方保留灌肠。每晚1次,1个月为1个疗程,治疗2个疗程后采用ELISA法分别检测两组患者血清白介素(interleukin,IL)-6和肿瘤坏死因子(tumor necrosis factor,TNF)-α含量,观察两组患者治疗前后Sutherland疾病活动指数变化及临床疗效。结果两组患者临床疗效分布比较,差异有统计学意义(P<0.05)。治疗后两组血清IL-6、TNF-α含量,Sutherland疾病活动指数均较治疗前明显降低(P<0.05);两组治疗前后IL-6、TNF-α含量,Sutherland疾病活动指数差值比较,差异均有统计学意义(P<0.05)。结论肠炎Ⅰ号方保留灌肠治疗UC疗效显著,可以明显降低患者血清IL-6、TNF-α水平。Objective To investigate the clinical efficacy of Enteritis No. 1 prescription in the treatment of ulcerative colitis （UC） of large intestine damp-heat type and its effects on serum levels of inflammatory factors. Methods Sixty patients with UC of large intestine damp-heat type were equally and randomly divided into control group and treatment group. The control group received 1.0 g of mesalazine suppositories, while the treatment group received Enteritis No. 1 prescription retention enema. Both groups received two courses of treatment （once every night, 1 month for a course）. After two courses of treatment, serum levels of interleukin-6 （IL-6） and tumor necrosis factor-α （TNF-α） were measured by enzyme-linked immunosorbent assay. The serum levels of IL-6 and TNF-α, changes in Sutherland Disease Activity Index （SDAI）, and treatment outcomes were compared between the two groups. Results There was a significant difference in the distribution of treatment outcomes between the two groups （P〈0.05）. After treatment, both groups showed significantly reduced serum levels of IL-6 and TNF-α and SDAI （P〈0.05）. However, the treatment group had significantly greater reductions in the above indices than the control group （P〈0.05）. Conclusion Enteritis No.1 prescription retention enema can significantly reduce serum levels of IL-6 and TNF-α and has good clinical efficacy in the treatment of UC of large intestine damp-heat type.

关 键 词：肠炎Ⅰ号方 溃疡性结肠炎 大肠湿热型 白介素-6 肿瘤坏死因子-Α 

分 类 号：R574.62[医药卫生—消化系统]