microRNA在肝癌复发转移中的研究进展  

The research progress of microRNA in the recurrence and metastasis of hepatocellular carcinoma

作　　者：赵英安 李福军[1] ZHAO Ying＇an, LI Fujun(Department of General Surgery, The Second Hospital of Harbin Medical University, Harbin, 150001, P. R. China)

机构地区：[1]哈尔滨医科大学附属第二医院普外科,哈尔滨150001

出　　处：《中国普外基础与临床杂志》2018年第11期1403-1407,共5页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的总结microRNA在原发性肝细胞肝癌(hepatocellular carcinoma,HCC)复发及转移中的作用机制及其在临床中的可能的应用价值。方法查阅国内外的相关文献并进行综述。结果 microRNA在HCC的细胞增殖及凋亡中发挥着重要作用,不同分型的microRNA通过不同的作用靶点及分子通路来促进或抑制HCC的复发及转移。结论 microRNA在HCC的复发及转移中具有调控作用,深入研究microRNA在HCC复发及转移中的作用机制对HCC的复发预测及临床治疗均可提供巨大帮助,其有望成为HCC复发转移预测和治疗的新靶点。Objective To summarize the mechanism of microRNA in the recurrence and metastasis of hepatocellular carcinoma （HCC） and its possible clinical application. Methods The relevant literatures at home and abroad were reviewed to summarize the results of various scholars. Results microRNA played an important role in cell proliferation and apoptosis of HCC. microRNA of different types promoted or inhibited the recurrence and metastasis of HCC through different action targets and molecular pathways. Conclusions microRNA has a regulation role in the recurrence and metastasis of HCC, and the depth mechanisms study of microRNA in the recurrence and metastasis of HCC provides great significance to clinical therapy. The miRNA is expected to be one of the new target on the prediction and treatment of recurrence and metastasis in HCC.

关 键 词：MICRORNA 肝细胞肝癌 复发 转移 综述 

分 类 号：R735.7[医药卫生—肿瘤]