肿瘤缺氧微环境对光动力疗法抗肿瘤的影响  

Anti-tumor effect of photodynamic therapy in tumor hypoxia microenvironment

作　　者：王筱冰[1] 谢李芬[1] 吕明威 刘全宏[1] WANG Xiaobing;XIE Lifen;LU Mingwei;LIU Quanhong(School of Life Sciences,Shaanxi Normal University,Xi＇an 710119,Shaanxi,China)

机构地区：[1]陕西师范大学生命科学学院,陕西西安710119

出　　处：《陕西师范大学学报（自然科学版）》2018年第6期93-98,共6页Journal of Shaanxi Normal University：Natural Science Edition

基　　金：国家自然科学基金(81571834;81472846);陕西师范大学优秀青年教师学术骨干项目(16QNGG012);中央高校基本科研业务费专项资金特别项目(GK201802002)

摘　　要：光动力疗法(photodynamic therapy,PDT)作为一种新技术已被用于多种癌症的临床治疗,其中分子氧在肿瘤治疗过程中发挥着重要的作用。肿瘤缺氧微环境与肿瘤的发生、转移及肿瘤患者预后效果等密切相关,光动力疗法的治疗效果严重受限于肿瘤的缺氧微环境。本文从肿瘤缺氧微环境、缺氧诱导因子、糖酵解途径与光动力疗法的关系等方面就缺氧环境对肿瘤光动力疗法治疗效果的影响进行综合评述,旨在加强和促进对肿瘤缺氧微环境与光动力疗法治疗肿瘤的进一步研究,同时对缺氧环境下肿瘤的光动力疗法治疗进行了展望。Photodynamic therapy （PDT） has been used as a new technology in the clinical treatment of a variety of cancers, in which molecular oxygen plays an important role in the treatment of cancer. Tumor hypoxia microenvironment is closely related to the occurrence and metastasis of tumors and the prognosis of tumor patients. The therapeutic effect of PDT is severely limited by the hypoxic microenvironment of tumors. This article comprehensively reviews the effects of hypoxic environment on the therapeutic effects of photodynamic therapy in the aspects of tumor hypoxia microenvironment, hypoxia-inducible factor, glycolysis pathway and photodynamic therapy, aiming to strengthen and promote tumor deficiency. Further research on the treatment of tumors by oxygen microenvironment and photodynamic therapy, and prospects for photodynamic therapy of tumors in hypoxic environment.

关 键 词：缺氧微环境 光动力疗法 缺氧诱导因子 糖酵解 

分 类 号：R730.5[医药卫生—肿瘤]