光热纳米材料在肿瘤治疗中的研究进展及生物反应性降解机制  

Research Progress of Photothermal Nanomaterials and Bioreaction Degradation Mechanism in Cancer Therapy

作　　者：刘珈[1] 武明花 Liu Jia;Wu Minghua(Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya Medical School,Central South University,Changsha 410013,Hunan,China.)

机构地区：[1]湖南省肿瘤医院,湖南长沙410003

出　　处：《生命科学仪器》2018年第4期92-97,共6页Life Science Instruments

摘　　要：肿瘤光热治疗(photothermal therapy,PTT)是在临床上继手术、放疗和化疗之后的又一具有很大潜力的肿瘤治疗新手段。基于肿瘤光热治疗的特点,对光热纳米材料的选择和要求就显得尤为重要,尤其是光热纳米材料的光热转换效率、表面修饰活性、生物组织相容性、生物降解性和低毒性等方面均是临床应用中需要考虑的关键因素。到目前为止,已经发展了四代纳米光热材料,包括贵金属纳米粒子、碳基纳米材料、金属和非金属化合物纳米材料以及有机染料等纳米材料,尽管这些光热纳米材料的研究均取得了一定的进展,但在临床应用上仍然面临着巨大的挑战,尤其是这些材料的生物反应性降解机制和代谢机制的研究将是临床应用安全问题的关键途径。Photothermal therapy （PTT） is an alternative new cancer treatment after surgery, radiotherapy and chemotherapy. Thinking about the characteristics of tumor photothermal therapy, the key factors of photothermal nanomaterials in clinical applications include theire photothermal conversion efficiency, surface modification activity, biocompatibility, biodegradability and low toxicity. With the development of photothermal nanomaterials, PTT holds immense potential in clinical translation. Up to now, four generation of photothermal nanomaterials have been developed, including noble metal nanoparticles, carbon based nanomaterials, metal and non-metallic compound nanomaterials and organic dyes. Although the research of these materials has made some progression, the clinical safety is still facing more challenges, especially in biodegradation mechanisms and metabolic mechanisms.

关 键 词：肿瘤光热治疗 光热纳米材料 生物反应性降解 生物代谢 

分 类 号：R730.5[医药卫生—肿瘤] TB383.1[医药卫生—临床医学]