放射性核素显像在化疗诱发心脏毒性监测中的应用  

Application of radionuclide imaging in the monitoring of chemotherapy-induced cardiotoxicity

作　　者：李彦峰[1] 黄世明[1] 林志春[1] Li Yanfeng;Huang Shiming;Lin Zhichun(Department of Nuclear Medicine,Affiliated Hospital of Logistics University of Chinese People＇s Armed Police Forces,Tianjin 300162,China)

机构地区：[1]天津武警后勤学院附属医院核医学科,300162

出　　处：《中华核医学与分子影像杂志》2018年第11期762-765,共4页Chinese Journal of Nuclear Medicine and Molecular Imaging

摘　　要：化疗是常规肿瘤治疗手段。随着临床诊断水平的提高、手术方法和化疗方案的不断改进，肿瘤患者的生存率得到了明显提高。然而，许多化疗药物在治疗肿瘤的同时也会对心脏产生毒性损伤，其中很多心脏损伤对患者而言是致命的，如心肌梗死、心力衰竭等。因此临床化疗过程中需对心脏毒性损伤进行监测，以及时发现并采取防治措施。相对于其他方法，基于分子水平的放射性核素显像具有独到优势。该文对目前化疗诱发心脏毒性的监测手段进行简要评价，重点对目前放射性核素显像在化疗诱发心脏毒性监测中的应用进行综述。Chemotherapy is commonly used for cancer treatment. With the development of diagnos- tic techniques, surgical methods and chemotherapy programs, the survival rate of cancer patients has been improved significantly. On the other hand, many chemotherapy drugs have cardiotoxicity and may cause fatal heart damage, such as myocardial infarction and heart failure. Therefore, it is necessary to monitor the oc- currence of cardiotoxicity so that preventive measures could be taken timely. Compared with other methods, radionuelide imaging based on the molecular level has its unique advantage. This review briefly evaluates the current monitoring methods of chemotherapy-induced cardiotoxicity and focuses on the application of radio- nuclide imaging in the monitoring of chemotherapy-induced cardiotoxicity.

关 键 词：肿瘤 药物疗法 心脏毒性 放射性核素显像 发展趋势 

分 类 号：R730.53[医药卫生—肿瘤] R730.44[医药卫生—临床医学]