心脉舒胶囊质控方法研究  

Quality Control Method of Xinmaishu Capsules

作　　者：丁晓明 孙露 侯静静 董林毅[3] DING Xiao-ming;SUN Lu;HOU Jing-jing;DONG Lin-yi(School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300072,China;Health Care and Family Planning Service Center for Women and Children in Hexi District,Tianjin 300072,China;School of Pharmacy,Tianjin Medical University,Tianjin 300070,China)

机构地区：[1]天津大学药物科学与技术学院,天津300072 [2]天津市河西区妇女儿童保健和计划生育服务中心,天津300072 [3]天津医科大学药学院,天津300070

出　　处：《中国药学杂志》2018年第21期1843-1846,共4页Chinese Pharmaceutical Journal

基　　金：天津市自然科学基金项目资助(17JCQNJC13300)

摘　　要：目的建立心脉舒胶囊的有效成分川芎药材中阿魏酸含量的测定方法。方法采用高效液相色谱法,Kromasil C18色谱柱(4. 6 mm×250 mm,5μm),流动相为乙腈-0. 3%乙酸(13∶87),流速1. 0 m L·min^(-1),紫外检测波长为322 nm。结果阿魏酸在1. 0～10. 0μg·m L^(-1)之间呈良好的线性关系(r=0. 999 8)。平均回收率为99. 57%(RSD=0. 75%,n=9)。结论所建立的方法稳定、可靠、灵敏、准确、简便,可用于心脉舒胶囊的质量控制。OBJECTIVE To establish an HPLC method for determination of ferulic acid in Ligusticum Wallichii,which is the active ingredient of Xinmaishu capsules. METHODS The content was determined by HPLC. The analysis was carried out on C18 （4. 6 mm × 250 mm,5 μm） column. The mobile phase consisted of acetonitrile-0. 3% acetic acid（ 13： 87）. The flow rate was 1.0 mL ·min^-1, and the UV detection wavelength was set at 322 nm. RESULTS The linearity range of the calibration curve for ferulic acid was from 1.0 to 10. 0μg · mL^-1（ r = 0. 999 8）. The average recovery rate was 99.57% with RSD of 0. 75% （n = 9）. CONCLUSION This method is sensitive, accurate,reproducible and simple. It can be used for the quality control of ferulic acid in Xinmaishu capsules.

关 键 词：心脉舒胶囊 阿魏酸 高效液相色谱法 川芎 质量控制 薄层色谱法 

分 类 号：R917[医药卫生—药物分析学]