血糖控制对老年2型糖尿病伴慢性牙周炎患者牙周状况的影响  

Effect of blood glucose level on periodontal status in elderly patients with type 2 diabetes mellitus and chronic periodontitis

作　　者：苏哲君[1] 王鹏[1] 霍峰[1] 李毅萍 陈雪[1] 赵维川[3] SU Zhe-jun;WANG Peng;HUO Feng;LI Yi-ping;CHEN Xue;ZHAO Wei-chuan(Department of Stomatology,Affiliated Hospital of Chengde Medical College,Hebei Chengde 067000,China;XiangYa Stomatological Hospi-tal,Central South University,Hunan Changsha 410078,China;Department of clinical laboratory,Affiliated Hospital of Chengde Medical College,Hebei Chengde,067000,China.)

机构地区：[1]承德医学院附属医院口腔科,河北承德067000 [2]中南大学湘雅口腔医(学)院,湖南长沙410078 [3]承德医学院附属医院检验科,河北承德067000

出　　处：《临床口腔医学杂志》2018年第10期619-622,共4页Journal of Clinical Stomatology

基　　金：河北省科技计划项目(17277760D);承德市科学技术研究与发展计划项目(20142052);政府资助临床医学优秀人才培养和基础课题研究项目(2016)

摘　　要：目的:探讨不同血糖控制水平的老年2型糖尿病(T2 DM)伴慢性牙周炎(CP)患者的牙周炎症状况,血清、全唾液中白细胞介素(IL)-6水平及临床意义。方法:纳入T2 DM伴CP患者48例,单纯CP患者20例,收集受检者非刺激全唾液及血清,采用酶联免疫吸附试验(ELISA)检测全唾液及血清中IL-6含量;并观察牙周状况进行统计分析。结果:T2 DM伴CP组全唾液及血清中IL-6含量均高于单纯CP组(P <0. 05);且T2 DM伴CP组中Hb A1c≥8%者全唾液及血清中IL-6含量高于Hb A1c <8%者全唾液及血清中IL-6含量(P <0. 05)。T2 DM伴CP组中Hb A1c≥8%的患者BI、PD、CAL均高于Hb A1c <8%患者(P <0. 05)。Hb A1c≥8%患者中重度牙周炎患病率高于Hb A1c <8%者。T2 DM伴CP组的Hb A1c与血清、唾液中IL-6水平、CAL呈正相关。结论:血清、全唾液中IL-6与老年T2 DM伴CP患者牙周炎发生发展密切相关。血糖控制不佳的老年T2 DM伴CP患者牙周炎症损害程度较高。Hb A1c≥8%的老年T2 DM伴CP患者中重度牙周炎所占比例高于Hb A1c <8%者。Objective： To investigate periodontal inflammation status in elderly patients with type 2 diabetes mellitus and chronic periodontitis at different blood glucose levels,serum and total saliva IL-6 levels and clinical significance. Methods： The total saliva and serum were collected from 48 patients with type 2 diabetes and chronic periodontitis（ DM ＋ CP） and20 cases of simple periodontitis（ CP）. The content of IL-6 in whole saliva and serum was detected by enzyme linked immunosorbent assay（ ELISA）. All the subjects were examined for periodontal status and analyzed statistically. Results： The content of IL-6 in all saliva and serum of group DM ＋ CP was higher than that of group CP（ P〈0. 05）. And（ DM ＋ CP） group Hb A1 c ≥ 8% IL-6 in saliva and serum were higher than that of Hb A1 c 〈8% saliva and serum IL-6 levels（ P〈0. 05）.The levels of BI,PD,CAL in Hb A1 c ≥ 8% patients of DM ＋ CP group were higher than that of Hb A1 c 〈8% patients（ P〈0. 05）. Hb A1 c ≥ 8% patients with moderate to advanced periodontitis prevalence was higher than patients with Hb A1 c 8%. Hb A1 c in group DM ＋ CP was correlated with IL-6 level in serum and saliva. Conclusion： IL-6 in serum and total saliva is closely related to the occurrence and development of periodontitis in elderly patients with type 2 diabetes mellitus and chronic periodontitis. Elderly Patients with type 2 diabetes and chronic periodontitis with poor glycemic control have a higher degree of periodontal inflammation. The proportion of moderate to advanced periodontitis in elderly patients with T2 DM and CP Hb A1 c ≥ 8% was higher than that of Hb A1 c 8%.

关 键 词：2型糖尿病 糖化血红蛋白 慢性牙周炎 IL-6 全唾液 

分 类 号：R781.4[医药卫生—口腔医学]