白内障超声乳化联合国产可折叠人工晶状体植入术后的安全性早期观察  

Observation of the early stage safety of phacoemulsification combined with domestic foldable intraocular lens implantation

作　　者：吴敬明[1] 李云峰 赵周婷[1] 王帅南 宋武莲[2] WU Jingming;LI Yunfeng;ZHAO Zhouting;WANG Shuainan;SONG Wulian(Department of Ophthalmology,the 211th Hospital of PLA,Heilongjiang Province,Harbin,150080,China;Department of Ophthalmology,the 2nd Affiliated Hospital of Harbin Medical University,Heilongjiang Province,Harbin,150001,China)

机构地区：[1]解放军第211医院眼科,黑龙江哈尔滨150080 [2]哈尔滨医科大学附属第二医院眼科,黑龙江哈尔滨15000

出　　处：《中国医药导报》2018年第33期76-79,共4页China Medical Herald

摘　　要：目的评价白内障超声乳化联合国产可折叠人工晶状体(IOL)植入术后早期的安全性。方法 2017年10～11月在解放军第211医院眼科就诊的14例白内障患者(18眼)植入A1-UV型一片式可折叠IOL。记录术中并发症。术后1 d、3 d、1周、2周随访,测量并记录患眼的前房深度、角膜平均曲率、非接触眼压、角膜内皮细胞密度、裂隙灯显微镜检查结果。采用SPSS 20.0对结果进行统计分析。结果角膜平均曲率、前房深度、非接触眼压在不同随访期的差异均无统计学意义(F=0.991,P=0.418;F=3.244,P=0.092;F=1.445,P=0.229)。术后1 d、3 d、1周、2周的角膜内皮细胞密度均比术前显著减少(F=19.816,P <0.001)。术后无一例患者出现前房渗出;仅术后1 d出现轻度球结膜水肿,术后3 d恢复到术前水平;在术后1～3 d出现轻度房水细胞和角膜水肿,术后1周恢复到术前水平;在术后1 d～1周出现轻度房水闪辉和球结膜充血,术后2周恢复到术前水平。结论超声乳化联合国产可折叠IOL植入术对人眼内环境的扰动较小,术后恢复快。国产A1-UV型可折叠IOL、HS-Ⅰ推注器和SI-Ⅰ导入头均具有良好的生物相容性和安全性。Objective To evaluate the safety of early stage in phacoemulsification combined with domestic foldable intraocular lens （IOL） implantation. Methods From October to November 2017, 14 cases of cataract patients （18 eyes） who were treated in the Department of Ophthalmology in the 211th Hospital of PLA were implanted with A1-UV one-piece foldable IOL. Intraoperative complications were recorded. The patients were followed up at 1 day, 3 days, 1 week and 2 weeks after operation. The anterior chamber depth, corneal average curvature, non-contact intraocular pressure, corneal endothelial cell density and slit lamp microscopy were measured and recorded. The result was analyzed by SPSS 20.0. Results There were no significant differences in corneal mean curvature, anterior chamber depth and non-contact intraocular pressure among different follow-up times （F = 0.991, P = 0.418; F = 3.244, P = 0.092; F = 1.445, P = 0.229）. The corneal endothelial cell density was significantly decreased at 1 d, 3 d, 1 week and 2 weeks after operation （F = 19.816, P ＜ 0.001）. No patient developed exudation of the anterior chamber after operation. Only mild conjunctival edema occurred 1 day after operation, and recovered to the preoperative level 3 days after operation. Mild postoperative aqueous humor cells and corneal edema occurred 1 day to 3 days after operation, and recovered to the preoperative level 1 week after operation. Mild aqueous flashes and bulbar conjunctival congestion occurred 1 day to 1 week after operation, and returned to preoperative level 2 weeks after operation. Conclusion Phacoemulsification combined with domestic foldable IOL implantation has little perturbation to the human eye and quick postoperative recovery. Domestic A1-UV foldable IOL, HS-Ⅰ injector and SI-Ⅰ import head all have good biocompatibility and safety, which is worth of clinical promotion and application.

关 键 词：国产可折叠IOL 安全性 生物学参数 角膜内皮细胞密度 炎性反应 

分 类 号：R779[医药卫生—眼科]