病毒性肝硬化患者血浆输注前后凝血功能指标的变化分析  

Analysis of Changes in Coagulation Function Indexes before and after Plasma Infusion in Patients with Viral Cirrhosis

作　　者：孙小敏 高莉莉[2] SUN Xiao- min, GAO Li -li(Yan＇ an Center Blood Station, Shaanxi Yan＇ an 716000, China; Department of Blood Transfusion, Affiliated Hospital of Yan＇ an University, Shaanxi Yan＇ an 716000, China)

机构地区：[1]延安市中心血站,陕西延安716000 [2]延安大学附属医院输血科,陕西延安716000

出　　处：《现代检验医学杂志》2018年第6期149-152,共4页Journal of Modern Laboratory Medicine

摘　　要：目的回顾性分析病毒性肝硬化患者血浆输注前后凝血功能指标的变化情况。方法以2014年6月～2016年6月延安大学附属医院所有诊断为病毒性肝硬化且首次输注血浆的86例住院患者病例资料为研究对象,采用凝固法检测凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)和纤维蛋白原(FIB)四项,胶乳免疫比浊法检测D-二聚体(D-Dimer,D-D)和纤维蛋白降解产物(fiber protein degradation product,FDP)。结果病毒性肝硬化患者输注血浆后PT值显著降低,APTT延长,D-D和FDP显著增高,差异均有统计学意义(t=8.00,4.46,7.07,8.27,均P<0.05),以年龄段、性别分组均有显著性变化,差异有统计学意义(P<0.05);病毒性肝硬化患者输注血浆前TT﹑FIB和输注血浆后相比无显著性变化(t=0.78,1.16,均P>0.05),以年龄段、性别分组均无显著性变化,差异无统计学意义(P>0.05)。结论病毒性肝硬化患者输注血浆后凝血功能得到改善。Objective To retrospectively analyze the changes of coagulation function indexes before and after plasma infusion in patients with viral cirrhosis. Methods From June 2014 to June 2016,all the 86 inpatients who were diagnosed with viral cirrhosis and the first infusion of plasma were enrolled in the Affiliated Hospital of Yan＇ an University. The coagulation method was used to detect prothrombin time （PT）. Activated partial thromboplastin time （APTT）, thrombin time （TT）, fibrinogen （FIB） ,latex immunoturbidimetric assay for D-dimer （DD） , fibrin degradation products （Fiber protein degradation product,FDP）. Results After transfusion of plasma in patients with viral cirrhosis, the PT value was significantly decreased, APTT was prolonged, and DD and FDP were significantly increased （t =8.00,4.46,7.07,8.27, all P〈0.05）, and were significantly grouped by age and sex. The difference of sexual change was statistically significant（P〈0.05）. There was no significant change in plasma TT, FIB and plasma infusion in patients with viral cirrhosis （ t =0.78,1.16, P〉0.05）. There were no significant changes inage group and gender group （P〉0.05）. The difference was not statistically significant. Conclusion Patients with viral cirrhosis had improved blood coagulation after infusion of plasma.

关 键 词：病毒性肝硬化 血浆输注 凝血功能 

分 类 号：R575.2[医药卫生—消化系统] R457.1[医药卫生—内科学]