脑梗死急性期淡漠与超敏-C反应蛋白、血尿酸、认知障碍的相关性  

Relationship of apathy in acute cerebral infarction and hypersensitivity-C heactive protein, blood uric acid and cognitive impairment

作　　者：连云芝 Lian Yunzhi(Department of Laboratory,the People＇s Hospital of Jincheng,Jincheng 048026,China)

机构地区：[1]山西省晋城市人民医院检验科,048026

出　　处：《中国实用医刊》2018年第20期17-20,共4页Chinese Journal of Practical Medicine

摘　　要：目的 分析脑梗死急性期淡漠与超敏-C反应蛋白（hs-CRP）、血尿酸（UA）、认知障碍的相关性,为脑梗死急性期淡漠管理提供依据.方法 选择2017年1月至2018年4月晋城市人民医收治的脑梗死患者84例.在卒中2周内,采用情感淡漠量表（MAES）评估患者的情感淡漠情况,分别评价认知、情感、行为三个方面,总分在0～42分,分值越高,则情感淡漠越严重,得分≥14分,即可诊断为情感淡漠.同时采用简易精神状态检查评估患者认知功能障碍,在入院时、进行评价时采集肘部静脉血检测hs-CRP、UA.结果 84例脑梗死患者MAES评分为5～31（11.5±6.3）分,其中≥14分25例.情感淡漠患者的简易智能状态检查量表（MMSE）评分低于无情感淡漠患者,情感淡漠患者入院时与评估时hs-CRP、UA高于无情感淡漠患者,情感淡漠患者hs-CRP、UA变化幅度高于无情感淡漠患者,差异有统计学意义（P〈0.05）.MAES评分与MMSE评分、入院时hs-CRP与UA存在相关性,差异有统计学意义（P〈0.05）.结论 脑梗死急性期淡漠与hs-CRP、UA、认知障碍存在相关性,入院时hs-CRP、UA水平越高,认知损伤越严重,出现淡漠的风险也越高.Objective To analyze the relationship between apathy in the acute phase of cerebral infarction and acute hypersensitivity-C-reactive protein （ hs-CRP ） , uric acid （ UA ） , and cognitive impairment.Methods Eighty-four cases of cerebral infarction admitted to the People ＇s Hospital of Jincheng from January 2017 to April 2018 were selected .Within 2 weeks of stroke , the emotional apathy of the patients were assessed by emotional apathy scale , the cognitive , emotional and behavioral aspects respectively .The total score was between 0 and 42 points .The higher the score was , the more serious the apathy was, and the score was more than 14 points, which can be diagnosed as emotional apathy .Simple mental state examination was used to assess the cognitive impairment in patients .At the time of admission and assessment , elbow venous blood was measured for hs-CRP and UA.Results The MAES score ranged from 5 to 31 points, with an average of （ 11.5 ±6.3 ） points, of which 25 patients with≥14 points.The three aspects of cognition , emotion and behavior were evaluated respectively .The hs-CRP and UA levels were higher in the patients with emotional apathy than those in the patients without emotional apathy on admission and during assessment .The patients with emotional apathy had a higher change range of hs-CRP, UA levels than the patients without emotional apathy , and the differences were significant （ P〈0.05 ） .MAES score is correlated with MMSE , hs-CRP and UA levels at admission （P〈0.05）.Conclusions Apathy in the acute phase of cerebral infarction is correlated with hs-CRP, UA, and cognitive impairment .The higher the levels of hs-CRP and UA at admission , the more severe the cognitive impairment and the higher the risk of apathy .

关 键 词：脑梗死 急性期 淡漠 超敏-C反应蛋白 血尿酸 认知障碍 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R446.6[医药卫生—临床医学]