血清IL-15水平与阿尔茨海默病及轻度认知功能障碍的关系  

Relationship between serum levels of IL-15 and Alzheimer disease and mild cognitive impairment

作　　者：毛媛媛[1] 滕海英[1] 张钱林[2] 许春艳 王卫红[1] Mao Yuanyuan;Teng Haiying;Zhang Qianlin;Xu Chunyan;Wang Weihong(Department of Neurology,the 13th Division of Xinjiang Production and Construction Corps Red Star Hospital,Hami 839000,China;Department of Neurology,Henan Provincial People＇s Hospital,Zhengzhou 450003,China)

机构地区：[1]新疆生产建设兵团第十三师红星医院神经内科,新疆维吾尔自治区哈密839000 [2]河南省人民医院神经内科,450003

出　　处：《中国实用医刊》2018年第20期23-26,共4页Chinese Journal of Practical Medicine

摘　　要：目的 探讨血清白细胞介素（IL）-15水平与阿尔茨海默病（AD）和轻度认知功能障碍（MCI）的关系.方法 选择新疆生产建设兵团第十三师红星医院2016年1月至2018年1月收治的AD患者53例、MCI患者47例作为研究对象,另选取同期体检的健康老年人40例作为对照组.采用酶联免疫吸附法检测血清IL-15含量,比较IL-15水平差异并分析IL-15与简易智能状态检查量表（MMSE）评分之间的相关性.采用Logistic回归和ROC曲线分析IL-15与AD及MCI的相关性及诊断性能.结果 AD组和MCI组血清IL-15水平显著高于对照组,且AD组显著高于MCI组（P〈0.05）.血清IL-15水平与受试者MMSE、定向力、记忆力、计算力、回忆力、语言能力均呈负相关（r〈0,P〈0.05）.血清IL-15水平增高是MCI和AD发病的危险因素.IL-15诊断MCI、AD及鉴别诊断MCI和AD的ROC曲线下面积（AUC）分别为0.777、0.870和0.653（均P〈0.05）.结论 血清IL-15水平与认知功能障碍的发生有一定相关性,与AD及MCI的发病密切相关,且对AD和MCI具有一定诊断和鉴别诊断价值.Objective To investigate the relationship between serum interleukin-15 （ IL-15 ） and Alzheimer＇s disease （ AD） and mild cognitive impairment （ MCI） .Methods A total of 53 patients with AD and 47 patients with MCI in the 13 th Division of Xinjiang Production and Construction Corps Red Star Hospital from January 2016 to January 2018 were enrolled in this study , and 40 healthy elderly at the same period were selected as control group .The serum IL-15 level was detected by enzyme-linked immunosorbent assay and compared , the relationship between IL-15 and MMSE scores was analyzed . Logistic regression and ROC curves were used to analyze the correlation and diagnostic performance of IL-15 with AD and MCI .Results The serum IL-15 levels in the AD group and MCI groups were significantly higher than those in control group , and that in AD group was significantly higher than that in from January 2016 to January 2018 MCI group （ P〈0.05 ） .Serum IL-15 was significantly negatively correlated with MMSE, orientation, memory, computational power, recall ability, and language ability （r〈0, P〈0.05）.Increased serum IL-15 level was a risk factor for the onset of MCI and AD .The area under the ROC curve （ AUC） for IL-15 diagnosis of MCI , AD and differential diagnosis of MCI and AD were 0.777, 0.870 and 0.653 respectively （ all P〈0.05 ） .Conclusions Serum IL-15 level is correlated with the occurrence of cognitive impairment , and it is closely correlated with the pathogenesis of AD and MCI .It has certain diagnostic and differential diagnostic value for AD and MCI .

关 键 词：阿尔茨海默病 轻度认知功能障碍 白细胞介素-15 

分 类 号：R749.16[医药卫生—神经病学与精神病学]