吉非替尼联合复方苦参注射液对老年中晚期肺癌化疗减毒增效的作用  

Effect of Gefitinib combined with compound matrine injection on patients with advanced lung cancer after chemotherapy

作　　者：余少康[1] 靳枫[1] 王树滨[1] 李柱[1] 潘毅贞 Yu Shaokang;Jin Feng;Wang Shubin;Li Zhu;Pan Yizhen(Department of Oncology,Peking University Shenzhen Hospital,Shenzhen 518000,China)

机构地区：[1]北京大学深圳医院肿瘤内科,深圳518000

出　　处：《中国实用医刊》2018年第20期117-120,共4页Chinese Journal of Practical Medicine

摘　　要：目的 探讨吉非替尼联合复方苦参注射液对中晚期肺癌化疗老年患者减毒增效的作用.方法 选择北京大学深圳医院2016年12月至2018年5月收治的中晚期肺癌患者88例,随机分为对照组和观察组,每组44例.两组均采用常规放化疗方案.对照组给予吉非替尼片,1片/次,1次/d;治疗组在对照组基础上给予复方苦参注射液静脉滴注,12 ml/次,1次/d.两组连续治疗6周.比较两组近期临床疗效、骨髓抑制变化以及生活质量评分.结果 观察组近期总有效率为81.82％,高于对照组（59.09％,P〈0.05）.治疗后,观察组中性粒细胞、血小板、血红蛋白、白细胞计数显著高于对照组（P〈0.01）.观察组治疗后生活质量评分高于对照组（P〈0.01）.结论 吉非替尼联合复方苦参注射液能提高中晚期肺癌化疗老年患者的近期疗效,减轻血液学毒性,改善生活质量.Objective To investigate the effect of toxicity reduting and efficacy enhancing of Gefitinib combined with compound matrine injection on patients with advanced lung cancer after chemotherapy .Methods Eighty-eight patients with advanced lung cancer in Peking University Shenzhen Hospital from December 2016 to May 2018 were randomly divided into observation group and control group, with 44 cases in each group .Both groups were treated with routine chemotherapy regimens .The patients in control group were given Gefitinib , 1 tablet for 1 day.Based on the treatment in control group, the patents in treatment group were treated with compound matrine injection , 12 ml/time, once a day.Both groups were treated for 6 weeks.The recent efficacy, myelosuppression change , and life quality scores were compared between two groups .Results The recent total efficacy rate of observation group was 81.82％, which was higher than that of control group （59.09％, P〈0.05）.The number of neutrophils, hemoglobin, platelets, and white blood cells was obviously higher than those of control group after treatment（P〈0.01）.The life quality scores of observation group were obviously higher than those of control group （ P〈0.01 ） .Conclusions Gefitinib combined with compound matrine injection can improve the recent effects on advanced lung cancer after chemotherapy , and reduce the toxicity of hematology , improve the life quality .

关 键 词：吉非替尼 复方苦参注射液 肺癌 减毒增效 

分 类 号：R734.2[医药卫生—肿瘤]