CD70／CD27通路参与的免疫调节及CD70在肿瘤中的表达  

Immunological regulation of CD70/CD27 pathway and the expression of CD70 in tumor

作　　者：刘珍珍 孔英君[1] 孙文学[1] 李世敏[1] 张敏[1] 殷和松 Liu Zhenzhen;Kong Yingjun;Sun Wenxue;Li Shimin;Zhang Min;Yin Hesong(Department of Respiratory Medicine,First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院呼吸内科,150001

出　　处：《国际肿瘤学杂志》2018年第8期487-489,共3页Journal of International Oncology

摘　　要：CD70／CD27通路在人类免疫调节中扮演着重要的角色，其在免疫调节中的作用主要表现在促进T细胞的活化与增殖，诱导效应T细胞和记忆T细胞的分化与形成以及对调节性T细胞的干预上。另外在某些肿瘤细胞中，CD70高水平表达为肿瘤的免疫治疗提供了新的思路。CD70/CD27 pathway plays an important role in human immune regulation. The role of CD70/CD27 pathway in immune regulation is mainly to promote the activation and proliferation of T cells, induce the differentiation and formation of effeetor T cells and memory T cells, and interfere with regulatory T cells. In addition, the high level of CD70 expression in some tumor cells provides a new way for tumor immuno- therapy.

关 键 词：免疫 细胞 肿瘤 CD70/CD27通路 

分 类 号：R730.51[医药卫生—肿瘤]