生长抑制因子基因1（ING1）——新型抗癌治疗中的潜在靶点  

Inhibitor of growth 1（ING1）-a novel potential therapeutic target in anti-cancer treatment

作　　者：胡思婧 高杉[1] 王杨 刘慧迪[1,3] Hu Sijing;Gao Shan;Wang Yang;Liu Huidi(Genomics Research Center,College of Pharmacy,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学药学院基因组中心,150081 [2]齐齐哈尔市第一医院病理科,161000 [3]中加HMU-UCFM感染与基因组学研究所,161000

出　　处：《国际遗传学杂志》2018年第5期378-383,共6页International Journal of Genetics

基　　金：国家自然科学基金（81671980、81271786、NIH81161120416）;黑龙江省大学生创新创业项目（201410226047、1022620152398、201610226095、201610226094、201710226073）;国家留学基金（201508230143）;黑龙江省卫生计生委科研课题（2016-188）;黑龙江省教育厅预算科研项目（20091005000218）;中国博士后科学基金（2018M630380）;黑龙江省普通本科高等学校青年创新人才培养计划（UNPYSCT-2018064）

摘　　要：ING1基因是Rb-E2F信号通路的重要调控因子，具有多种生物学功能，在肿瘤细胞增殖、凋亡、衰老以及DNA修复和血管生成等方面发挥重要作用。现已证明ING1与头颈部鳞状细胞癌、胃癌、肝癌、大肠癌、乳腺癌、前列腺癌等恶性肿瘤的进展有着密不可分的关系。本文将阐述ING1基因的发现历程和结构，及其生理功能，并将对ING1作为抑癌靶点的作用以及其可能机制做着重介绍。ING1 is an important regulator of Rb-E2F pathway. ING1 is involved in various biological functions, such as cancer cell proliferation, apoptosis, aging, DNA repair, and angiogenesis. It has already been reported that ING1 could be involved in cancer progressions in head and neck squamous carcinoma, gastric carcinoma, liver cancer, colon cancer, prostate cancer, and breast cancer. Here we will review the discovery and structures of ING1 gene, as well as its physiological function. Furthermore, we will focus on the therapeutic target function of ING1 in anti-cancer treatment and its potential mechanism.

关 键 词：ING1基因 抑癌基因 潜在机制 DNA修复 

分 类 号：R730.5[医药卫生—肿瘤]