HPV L1壳蛋白、Survivin蛋白及高危型HPV感染在不同程度宫颈病变中的相关性研究及临床价值  

Correlation and clinical value of HPV L1 shell protein,Survivin protein and high risk HPV infection in different degree of cervical lesions

作　　者：张韦 韩萍 肖远革 赵东婷 ZHANC wei;HAN Ping;XIAO Yuan-Ge(Affiliated Hospital of North China University of Science and Technology,Tangshan,Hebei 063000,China)

机构地区：[1]华北理工大学附属医院,河北唐山063000

出　　处：《中国妇幼保健》2018年第22期5258-5261,共4页Maternal and Child Health Care of China

摘　　要：目的分析HPV L1壳蛋白、Survivin蛋白及hrHPV阳性在不同程度宫颈病变中的表达情况,探讨三者在宫颈病变中的筛查、诊断及临床价值。方法收集2016年9月-2017年7月于华北理工大学附属医院就诊的符合入组条件(无宫颈上皮内瘤变史及恶性肿瘤病史,无宫颈手术史、盆腔放化疗病史,无免疫系统抑制性疾病史或服用免疫抑制剂史,且近期内无妊娠史者)、行宫颈TCT检查结果异常和/或hrHPV检测阳性患者分别行阴道镜检查并对可疑部位行活检组织病理学检查,比较不同程度宫颈病变患者中HPV L1壳蛋白、Survivin蛋白及hrHPV阳性的表达情况。结果符合入组患者215例,其中正常宫颈组70例,低级别上皮内病变(LSIL)组53例,高级别上皮内病变(HSIL)组64例,宫颈癌(SCC)组28例。HPV L1壳蛋白在正常宫颈组、LSIL组、HSIL组和SCC组中的阳性率分别为55.71%、52.83%、19.12%和0.00%,差异有统计学意义(P<0.05)。Survivin蛋白在4个组中的阳性率分别为2.86%、9.43%、14.71%和53.57%,SCC组阳性率明显高于其他3个组,差异有统计学意义(P<0.05)。hrHPV阳性率在4个组中分别为21.43%、30.19%、42.65%及92.86%,差异有统计学意义(P<0.05)。结论 HPV L1壳蛋白、Survivin蛋白、hrHPV检测在不同程度宫颈病变患者中具有一定的筛查、诊断及临床价值,三者的联合筛查可作为宫颈癌前病变进展的重要临床指标。Objective To investigate the expressions of HPV L1 shell protein, Survivin protein and hrHPV positive in cervical le- sions, and to explore the screening, diagnosis and clinical value of cervical lesions. Methods The patients were enrolled in the Affiliated Hospital of North China University of Science and Technology from September 2016 to July 2017 （ no history of cervical intraepithelial neo- plasia and malignancy, no history of cervical surgery, no history of pelvic radiotherapy and chemotherapy, no immune system suppression history of the disease or the history of taking immunosuppressive drugs, and no recent pregnancy）, the patients whose cervical TCT test were abnormal and （or） hrHPV test were positive were examined by colposcopy and biopsy histopathology of suspected sites. The expressions of HPV L1 shell protein, Survivin protein and hrHPV positive in patients with different degrees of cervical lesions were compared. Results There were 215 patients, including normal group （70 cases with normal cervix） , 53 cases of low grade intraepithelial lesion （LSIL）, 64 cases of high grade intraepithelial lesion （HSIL） , 28 cases of cervical cancer （SCC）. The positive rates of HPV L1 shell protein were 55.71%, 52. 83%, 19. 12% and 0. 00% in normal group, LSIL group, HSIL group and SCC group respectively, the differences were statistically significant （P〈0.05） . The positive rates of Survivin protein in the four groups were 2. 86%, 9.43%, 14.71% and 53.57%, respectively. The Survivin protein positive rate of SCC group was significantly higher than that of the other three groups, the differences were statistically significant （P〈0. 05） . The positive rates of hrHPV were 21.43%, 30. 19%, 42. 65% and 92. 86% in the four groups, respectively, the differences were statistically significant （P〈0.05） . Conclusion HPV L1 shell protein, Survivin protein and hrHPV have screening, diagnosis and clinical values in patients with cervical lesions at different degrees. The combined screening

关 键 词：宫颈病变 人乳头状瘤病毒 HPV L1壳蛋白 SURVIVIN蛋白 

分 类 号：R737.33[医药卫生—肿瘤]