杨志敏治疗阳虚质疲劳状态人群膏方用药规律挖掘研究  

Data mining analysis of the ointment medication by Prof. Yang Zhimin treating yang deficiency and fatigue state patients

作　　者：黄遂和 丘宇慧 陈瑶瑶 管桦桦[3] 张晓轩[3] 徐福平 原嘉民 Huang Suthe;Qiu Yuhui;Chen Yaoyao;Guan Huahua;Zhang Xiaoxuan;Xu Fuping;Yuan Jiamin(Master of 2015,Guangzhou University of Chinese Medicine,Guangzhou 510105,China)

机构地区：[1]广州中医药大学,510105 [2]广州中医药大学第二临床医学院,510105 [3]广东省中医院扶阳流派工作室,广州510120 [4]颜德馨青方工作室 [5]健康状态辨识与中医治未病创新团队

出　　处：《国际中医中药杂志》2018年第11期1045-1048,共4页International Journal of Traditional Chinese Medicine

基　　金：广东省中医院颜德馨膏方工作室[中医二院（2014）89号-6];广东省中医院扶阳流派传承工作室项目（2013KT1517）;广东省中医院岭南中医学术流派临床研究专项（YN2014LN03）

摘　　要：目的 分析和挖掘杨志敏教授治疗阳虚质疲劳状态人群的膏方用药规律。方法 整理2010年10月－2013年1月广东省中医院治未病中心杨志敏教授门诊治疗阳虚质疲劳状态人群的膏方处方，使用SPSS 18.0软件对药物种类、频次进行分析，并采用Clementine 12.0软件进行药物二项、六项关联规则分析挖掘，探寻核心组方。结果 共纳入膏方处方62首，涉及中药193味，其中附子为使用频次最多的药物，且频次前36名的药物中，化湿药占了22.2%；通过关联规则分析发现，使用最多的药对涉及四逆汤、当归四逆汤及金匮肾气丸中的药物，如“附子配干姜”“附子配炙甘草”“干姜配炙甘草”等；得出以“附子、炙甘草、干姜、砂仁”为核心的潜阳丹合四逆汤加减组方及以“山药、菟丝子、当归、炙甘草”为核心的景岳菟丝煎加减组方。结论 “健脾益肾、温阳化湿”“温潜阳气、阴中求阳”是杨教授膏方辨证治疗阳虚质疲劳状态人群的用药思路。Objective The purpose of this research is to use modern statistical methods, to analyze the rules of cointment by Prof. Yang Zhimin treating yang deficiency and fatigue state patients, to increase the pertinence and to improve the clinical efficacy. Methods This paper analyzed 62 cases of Prof. Yang Zhimin in the treatment of the patients with yang deficiency and fatigue state from October 2010 to January 2013. The analyses were frequency analysis and association rules. Results Among the patients with yang-deficiency and fatigue, 193 Chinese medicine were used. The monkshood was the highest frequency. Dampness-transforming medicine accounts for about 22.2% in the top 36 frequency of medicine. Based on analyzing association rules, we found that the compatibility of medicine which were used more frequently came from Sini decoction, Danggui Sini decoction and Jinkui Shenqi pills, such as ＂monkshood and dried ginger＂, ＂monkshood and roasted liquorice＂,＂dried ginger and roasted liquorice＂, ＂monkshood and angelica＂, ＂monkshood and cornel＂, ＂monkshood and prepared rehmannia root＂ and ＂monkshood and yam＂. Futhermore, we found two new core prescription. One was Qian Yang Dan combined with Sini decoction consist of ＂monkshood, roasted liquorice, dried ginger, fructus amomi＂.The other one was Tu Si Jian consist of ＂yam, semen cuscutae, angelica, roasted liquorice＂. Conclusions ＂Invigorating spleen and kidney＂, ＂warming yang and dissipating dampness＂ and ＂hiding yang and Seeking Yang in Yin＂ are the habits and rules of the ointment medication by Prof. Yang Zhimin treating yang deficiency and fatigue state patients.

关 键 词：膏剂(中药) 杨志敏 阳虚 疲劳 数据挖掘 

分 类 号：R249[医药卫生—中医临床基础]