MiRNA21的表达变化在胃癌患者诊断中的意义  

The Significance of MiRNA21 Expression in the Diagnosis of Gastric Cancer

作　　者：杨安[1] 李曦[1] YANG An;LI Xi(Department of Digestive Internal Medicine,Peking University Shenzhen Hospital,Shenzhen 518035,Guangdong Province,China)

机构地区：[1]北京大学深圳医院消化内科,广东深圳518035

出　　处：《罕少疾病杂志》2018年第5期74-75,共2页Journal of Rare and Uncommon Diseases

基　　金：广东省深圳市卫生计生系统科研项目(201507019)

摘　　要：目的通过研究胃癌患者血清和组织中miRNA21的表达情况,了解其在胃癌发病过程中的意义。方法选取胃癌患者及正常健康对照组各20例,采用原位杂交的方法检测和实时定量PCR检测miRNA21的水平。结果胃癌组组织和血清中的miRNA21表达水平均较正常组升高,且差异具有统计学意义(P<0.05)。结论胃癌患者组织和血清中的miRNA21表达升高,可能为胃癌的诊断以及治疗提供新的方向。Objective To investigate the significance of the detection of miRNA21 expression in the serum and tissues of the patients with gastric cancer. Methods 20 patients with gastric cancer and 20 healthy controls were detected. And the expression of miRNA21 was evaluated by using the method of in situ hybridization and realtime quantitative polymerase chain reaction（PCR）. Results miRNA21 in the serum and tissues of patients with gastric cancer was higher than that in the healthy control group, the difference had statistical significance（P〈0.05）. Conclusion The upregulated expression of miRNA21 in the serum and tissues of the patients with gastric cancer might provide a new direction of diagnosis and therapy for gastric cancer.

关 键 词：胃癌 miRNA21 

分 类 号：R735.2[医药卫生—肿瘤]