前列腺肉瘤26例回顾性分析  

Prostate sarcoma: A retrospective analysis of 26 cases

作　　者：沈敏强 潘昊[1] 汪朔[1] 张明华[2] 叶发根[2] 杨荣华[2] SHEN Min-qiang;PAN Hao;WANG Shuo;ZHANG Ming-hua;YE Fa-gen;YANG Rong-hua(Department of Urology,The First Hospital of Zhejiang University School of Medicine,Hangzhou,Zhejiang 310003,China;Department of Urology,Huzhou Central Hospital,Huzhou,Zhejiang 313000,China)

机构地区：[1]浙江大学医学院附属第一医院泌尿外科,浙江杭州310003 [2]湖州市中心医院泌尿外科,浙江湖州313000

出　　处：《中华男科学杂志》2018年第11期983-986,共4页National Journal of Andrology

摘　　要：目的:总结前列腺肉瘤的诊治体会,阐述其诊疗及预后特点。方法:回顾分析1998年6月至2018年3月收治的26例前列腺肉瘤患者的临床资料。患者年龄15～64(41±14)岁,血清PSA 0. 35～5. 21 (1. 76±1. 18)μg/L,分别经前列腺穿刺活检、经尿道前列腺电切及手术活检或切除确诊为前列腺肉瘤。结果:26例患者病理诊断为平滑肌肉瘤11例,横纹肌肉瘤6例,梭形细胞肉瘤4例,纤维肉瘤4例,未分化肉瘤1例。24例获得随访,2例失访;随访时间3～18个月,平均13个月。随访病例中21例患者确诊后12个月内死亡,3例患者确诊后13～18个月死亡,均因肿瘤多发远处转移死亡。结论:前列腺肉瘤临床罕见,恶性程度较高,预后差。手术切除仍是治疗的主要方法。临床上应多种方法联合诊断和治疗前列腺肉瘤。Objective： To present our experience in the diagnosis and treatment of prostate sarcoma and the clinical and prognostic features of the malignancy. Methods： We retrospectively analyzed the clinical data on 26 cases of prostate sarcoma treated in our hospital from June 1998 to March 2018. The patients ranged in age from 15 to 64 years（ [41 ± 14]yr） and in the PSA level from 0. 345 to 5. 213 μg/L（ [1. 762 ± 1. 184] μg/L）,all diagnosed with prostate sarcoma by prostatic biopsy and pathological examination after transurethral resection of the prostate（ TURP）. Results： Postoperative pathological examination showed 11 cases of leiomyosarcoma,6 cases of rhabdomyosarcoma,4 cases of spindle cell sarcoma,4 cases of fibrosarcoma and 1 case of undifferentiated sarcoma among the total number of patients. Twenty-four of the patients were followed up for 3 to 18（ mean 13） months,of whom 21 died within 12 months and the other 3 within 13-18 months after diagnosis,all due to extensive metastases. Conclusion： Prostate sarcoma is a rare malignancy clinically,highly aggressive and with very poor prognosis. Surgery remains the main treatment option,but multiple disciplinary diagnosis and treatment could probably achieve a better prognosis for prostate sarcoma.

关 键 词：前列腺肉瘤 治疗 预后 

分 类 号：R737.25[医药卫生—肿瘤]