青年性脑卒中与遗传因素研究进展  

Research Progress of Youth Cerebral Apoplexy and Genetic Factors

作　　者：贺美文 喻明 HE Meiwen;YU Ming(Department of Neurology,Affiliated Hospital of Zunyi Medical College,Zuiyi 563000,China)

机构地区：[1]遵义医学院附属医院神经内科,贵州遵义563000

出　　处：《医学综述》2018年第22期4456-4460,共5页Medical Recapitulate

摘　　要：青年性脑卒中是脑卒中的一种,患者的发病年龄为15～45岁。影响青年脑卒中发病的危险因素有很多,包括吸烟、饮酒、高血压、高血脂、高血糖、肥胖、缺乏体育锻炼等。青年性脑卒中具有遗传易感性,肾素-血管紧张素-醛固酮系统、同型半胱氨酸、脂质代谢、凝血和纤溶系统、单基因遗传疾病等的基因异常可导致血脂异常、高凝状态、动脉粥样硬化、血栓形成,与青年性脑卒中的发生相关。因此,早期发现和筛查卒中遗传基因对预防脑卒中的发生具有重要意义。Youth cerebral apoplexy is a kind of stroke,with the onset age of 15-45 years old.There are many risk factors influencing the incidence of stroke among young people,including smoking,drinking,hypertension,hyperlipidemia,hyperglycemia,obesity,lack of physical exercise,etc.Youth cerebral apoplexy has a genetic predisposition.Genetics abnormality of renin-angiotensin-aldosterone system,homocysteine,lipid metabolism,blood coagulation and fibrinolysis system,single genetic diseases can cause dyslipidemia,high coagulation state,atherosclerosis,thrombosis,which are related to the occurrence of youth cerebral apoplexy.Therefore,early detection and screening of genetic genes for stroke have great significance in preventing stroke.

关 键 词：青年性脑卒中 遗传因素 肾素-血管紧张素-醛固酮系统 同型半胱氨酸 脂质代谢 凝血和纤溶系统 

分 类 号：R743.3[医药卫生—神经病学与精神病学]