广泛性焦虑障碍的重复经颅磁刺激治疗研究进展  

Research Progress of Transcranial Magnetic Stimulation in the Treatment of Generalized Anxiety Disorders

作　　者：许春杏 王骞 李红政[1] XU Chunxing;WANG Qian;LI Hongzheng(Mental Health Center,PLA 303rd Hospital,Nanning 530021,China)

机构地区：[1]解放军第三○三医院心理卫生科,南宁530021

出　　处：《医学综述》2018年第22期4491-4496,共6页Medical Recapitulate

基　　金：心理卫生应用性重点建设项目(FYJ2015W01);全军医学科学技术"十二五"计划课题(CWS11J278)

摘　　要：近年来,重复经颅磁刺激(r TMS)广泛用于治疗各种精神病。广泛性焦虑障碍(GAD)作为一种慢性精神疾病,日益受到学界的重视。有关GAD的药物治疗可能存在不良反应大、依从性差等缺点,故治疗存在局限性。目前相关研究认为rTMS可以作为GAD的一种治疗选择。但rTMS治疗GAD的机制尚不明确,并且在多种治疗方案中尚未能明确最佳刺激部位及刺激频率。近年来有关rTMS治疗GAD的临床研究也日益增多并逐渐改进,均得出rTMS治疗GAD疗效可靠的结论,但今后相关研究尚需在目前设计方案的基础上进一步完善。总之,rTMS治疗不良反应小,安全性相对较高,将在该领域有广阔的发展前景。Repetitive transcranial magnetic stimulation（rTMS） has been widely used in recent years as a treatment for a variety of psychiatric disorders.As a chronic psychiatric disorder,generalized anxiety disorder（GAD） has been receiving more academic attention recently.Medication for GAD may have some limitations such as high adverse effects and poor compliance.It is considered that rTMS can be a treatment option for GAD in current research. However,the mechanism of rTMS in the treatment of GAD is not clear,and the optimal stimulation site and frequency have not been determined in various treatment schemes. Recent clinical studies on the treatment of GAD by rTMS have also been increasing and improving gradually, all of which have reached the conclusion that the efficacy of rTMS in the treatment of GAD is reliable, but the future research needs to be further improved on the basis of the current design scheme.In conclusion, rTMS has relatively high safety and low adverse effects,which has a promising future in this field.

关 键 词：广泛性焦虑障碍 重复经颅磁刺激 刺激部位 刺激频率 选择性5-羟色胺再摄取抑制剂 

分 类 号：R749[医药卫生—神经病学与精神病学]