MAFG:癌症治疗潜在靶点  

MAFG: A promising target for cancer therapy

作　　者：杨玉容 李子涵 夏磊 张素君[2] 周志刚[3] 涂剑 YANG Yurong;LI Zihan;XIA Lei;ZHANG Sujun;ZHOU Zhigang;TU Jian(Institute of Pharmacy and Pharmacology,University of South China,Hengyang 421001,China;Medical Research Center,University of South China,Hengyang 421001,China;Department of Anesthesiology,the First Affiliated Hospital,University of South China,Hengyang 421001,China)

机构地区：[1]南华大学药学院,衡阳421001 [2]南华大学医学研究中心,衡阳421001 [3]南华大学附属第一医院麻醉科,衡阳421001

出　　处：《生命的化学》2018年第5期689-694,共6页Chemistry of Life

基　　金：南华大学2017年大学生创新团队;南华大学2017年高层次引进人才科研启动基金(24);南华大学2018年大学生创新性课题(192;197);国家自然科学基金资助项目(81541163);湖南省教育厅创新平台项目(15K111);湖南省分子靶标新药研究协同创新中心项目(2016-429)

摘　　要：碱性亮氨酸拉链家族转录因子V-Maf鸟类肌筋膜纤维肉瘤癌基因同源物(musculoaponeurotic fibrosarcoma, MAF) G在人正常组织表达较低,但在黑色素瘤、结肠直肠癌、肺癌和胆管细胞型肝癌等癌组织表达显著增强。通过网上收集肝细胞型肝癌(hepatocellular carcinoma, HCC)临床样本的公共数据库,发现MAFG在癌组织的表达显著高于癌旁组织,而且高表达MAFG的HCC患者预后差于低/中表达者。以上均提示MAFG是又一潜在的促癌因子。本文就MAFG在癌症中高表达的作用及其可能机制作一综述。Recent studies have found that the expression of V-Maf avian musculoaponeurotic fibrosarcoma oncogene homolog G, abbreviated to MAFG, was low in human normal tissues, while it was significant- ly higher in many cancers such as malignant melanoma, carcinoma of colon and rectum, lung cancer and cholangiocarcinoma, and so on. We have collected the clinical samples of hepatocellular carcinoma （HCC） from public database and found that MAFG expression was significantly higher in cancer tissues than that in paracancerous tissues. Furthermore, the prognosis of HCC patients with high expression of MAFG was worse than those with low/moderate expression. All above suggest that MAFG is another potential cancer promoter. This article has reviewed the role and 1oossible mechanisms of MAFG high expressed in the cancer.

关 键 词：MAFG 癌症治疗 潜在靶点 

分 类 号：R730.5[医药卫生—肿瘤]