亚太结直肠癌筛查评分系统在我国体检人群结直肠癌机会性筛查中的应用  

Application of Asia-Pacific Colorectal Screening (APCS) scoring system in physical examination population opportunistic screening for colorectal cancer in China

作　　者：翟爱军[1] 杜丽娜 张续乾 陈洪[1] 翟惠虹[2,3] 潘淑莉 申素芳[1] 郭艳青 武斌[1] 杨钰[1] Zhai Aijun;Du Lina;Zhang Xuqian;Chen Hong;Zhai Huihong;Pan Shuli;Shen Sufang;Guo Yanqing;Wu Bin;Yang Yu(Department of Gastroenterology and Hematology,No.731 Hospital of China Aerospace Science ＆ Industry Corporation,Beijing 100074,China;Department of Gastroenterology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;National Clinical Research Center for Digestive Diseases,Beijing 100050,China)

机构地区：[1]中国航天科工集团七三一医院消化及血液内科,北京100074 [2]首都医科大学附属北京友谊医院消化内科,北京100050 [3]国家消化系统疾病临床医学研究中心,北京100050

出　　处：《中华胃肠内镜电子杂志》2018年第3期114-117,共4页Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition)

基　　金：中国航天科工集团公司医疗卫生科研(2017-JKBZ-004);首都发展基金(2018-3-1115)

摘　　要：目的 探讨亚太结直肠癌（CRC）筛查评分系统（APCS）在我国体检人群CRC机会性筛查中的应用价值。 方法 前瞻性收集2017年6月至2018年2月经中国航天科工集团七三一医院体检中心行结肠镜检查的健康无症状体检人群资料，应用APCS评分系统评估不同危险分层中结直肠肿瘤的检出率、灵敏度、特异度。 结果 共纳入无症状人群294例，接受结肠镜检查前评分，平均年龄（57.28±9.85） 岁，APCS评分分为低危组（AR，63例）、中危组（MR，206例）、高危组（HR，25例），结直肠肿瘤检出例数（率）分别为3（4.76%）、41（19.9%）、6（24.0%），HR组人群结直肠肿瘤的检出率为AR组人群的6.32倍（ 95%CI：1.45-27.71，P=0.011 ）；MR组人群结直肠肿瘤的检出率为AR组人群的1.27倍 （95%CI：0.48-3.38，P= 0.631）；HR＋MR对结直肠肿瘤检出的灵敏度为94.0%，特异度为24.6%。 结论 APCS评分系统针对我国体检人群进行结肠镜检查的必要性具有重要指导意义，对于评分为HR＋MR人群应尽早接受结肠镜检查。Objective To evaluate the application value of Asia- Pacific Colorectal Screening （APCS） scoring system in physical examination population opportunistic screening for colorectal cancer in China. Methods In a prospective study,data of physical examination population in No.731 Hospital of China Aerospace Science ＆ Industry Corporation（CASIC）from June 2017 to February 2018 were prospectively collected.APCS score was used to evaluate the detection rate of Colorectal neoplasms,sensitivity and specificity in groups of different risks collected. Results Totally,there were 294 subjects with mean age of 57.28±9.85 years.APCS score was accounted before they underwent routine colonoscopy.APCS score was classified as average risk（AR）,moderate risk（MR）and high risk（HR）,which included 63,206 and 25 cases ,respectively.The number and detection rates of colorectal neoplasia in AR,MR and HR groups were 3（4.76%）,41（19.9%）and 6（24.0%）,respectively.Detection rate of colorectal neoplasia in the HR group showed 6.32 times of that in the AR group（95% CI：1.45- 27.71,P =0.011）.Detection rate of eoloreetal neoplasia in the MR group showed 1.27 times of that in the AR group （95% CI：0. 48-3. 38 ,P = 0.631 ）. The sensitivity- and specificity were 94.0% and 24.6% , respectively in the HR group and MR group. Conclusion APCS score can be widely applied for guiding the necessity routine eolonoseopy opportunistic screening in physical examination population. The MR and HR groups evaluated by APCS could early undergo eolonoseopy.

关 键 词：亚太结直肠癌筛查评分系统 机会性筛查 结直肠肿瘤 体检人群 

分 类 号：R735.34[医药卫生—肿瘤]