局部氧疗治疗白内障术后角膜水肿  

Effect of local oxygen therapy on corneal edema after cataract surgery

作　　者：邓彤彤 陈俊杰 张剑利[1] 黄燕[1] Deng Tongtong;Chen Junjie;Zhang Jianli;Huang Yan(Department Ophthalmology of Lianjiang People＇s Hospital,Zhanjiang 524400,China;The Second Affiliated Hospital of Guangdong MedicalUniversity,Zhanjiang 524000,China)

机构地区：[1]廉江市人民医院眼科,广东湛江524400 [2]广东医科大学附属第二医院眼科,广东湛江524000

出　　处：《分子影像学杂志》2018年第4期554-557,共4页Journal of Molecular Imaging

摘　　要：目的探讨局部氧疗治疗白内障术后角膜水肿的疗效。方法选取两个医院白内障手术术后角膜水肿患者66例,随机分成对照组和观察组,每组33例。对照组患者术后1 d开始予妥布霉素地塞米松滴眼液局部滴眼治疗,4次/d。观察组在对照组治疗基础上,术后1 d开始行局部氧疗,氧流量为5 L/min,1 h/次,2次/d。结果观察组患者术后第3、7、14和28天中央角膜厚度显著低于对照组患者(P<0.05),观察组患者术后第3、7、14和28角膜内皮细胞计数显著高于对照组患者(P<0.05)。观察组患者术后第3、7、14、28天内皮细胞面积显著高于对照组患者(P<0.05)。观察组患者术后第7、14和28天变异系数显著低于对照组患者(P<0.05)。观察组患者术后第14和28天六边形细胞百分率显著高于治疗前(P<0.05)。结论局部氧疗可有效减轻白内障术后角膜水肿,保留更多有功能的角膜内皮细胞,值得在临床上推广。Objective To explore the effect of local oxygen therapy on corneal edema after cataract surgery. Methods 66 cornealedema patients after cataract surgery were assigned to the control group and experimental group （n=33）. Patients in the controlgroup were treated with tobramycin and dexamethasone eye drops four times daily for 28 d postoperatively, and patients inthe experimental group received local oxygen therapy at a flow rate of 5 L/min twice daily for 28 d besides the eye dropspostoperatively. Results Central corneal thickness was significantly lower in the experimental group than that in the controlgroup in 3, 7, 14 and 28 d postoperatively （P〈0.05）. Endothelial cell count was significantly higher in the experimental groupthan that in the control group in 3, 7, 14 and 28 d postoperatively （P〈0.05）. Endothelial cell size was significantly lower in theexperimental group than that in the control group in 3, 7, 14 and 28 d postoperatively （P〈0.05）. Coefficient of variation wassignificantly lower in the experimental group than that in the control group in 7, 14 and 28 d postoperatively （P〈0.05）.Hexagonality was significantly higher in the experimental group than that in the control group in 14 and 28 d postoperatively（P〈0.05）. Conclusion Local oxygen therapy could effectively relive corneal edema after cataract surgery and save morefunctional corneal endothelial cell, which is worth popularizing clinically.

关 键 词：局部氧疗 白内障术后 角膜水肿 

分 类 号：R779.66[医药卫生—眼科]