补精解毒方联合化疗治疗老年中晚期非小细胞肺癌40例  

Essence-supplementing Detoxifying Prescription Combined with Chemotherapy in Treating 40 Senile Patients with Advanced Non Small-cell Lung Cancer

作　　者：安青[1,2,3] 吴燕波 李伟兵[1,2,3] 包玉华 俞晨[1,2,3] AN Qing;WU Yanbo;LI Weibing;BAO Yuhua;YU Chen(Jiangsu Provincial Cancer Hospital,Nanjing 210029,China;Jiangsu Provincial Cancer Institute;Cancer Hospital Affiliated to Nanjing Medical University)

机构地区：[1]江苏省肿瘤医院,江苏南京210029 [2]江苏省肿瘤研究所 [3]南京医科大学附属肿瘤医院

出　　处：《西部中医药》2018年第10期76-79,共4页Western Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(编号81503528);江苏省中医药局科研项目(编号YB2017091)

摘　　要：目的:观察补精解毒方联合化疗治疗老年中晚期非小细胞肺癌临床疗效。方法:将80例患者随机分观察组和对照组,每组40例。对照组给予化疗,观察组在对照组治疗的基础上服用补精解毒方。观察2组患者的疾病控制率、临床获益率、体质量增加稳定率及治疗前后KPS评分提高率、毒副反应及化疗周期。结果:疾病控制率2组比较,差异无统计学意义(P>0.05)。临床获益率、体质量增加稳定率及KPS评分提高率观察组优于对照组(P<0.05),观察组副反应发生例数少于对照组平均化疗周期长于对照组。结论:补精解毒方联合化疗治疗中晚期非小细胞肺癌能改善患者生活质量,提高疾病控制率和临床获益率,且能够减轻化疗引起的不良反应,增强老年人对化疗的耐受性。Objective： To observe clinical effects of essence-supplementing detoxifying prescription joinedwith chemotherapy in treating senile patients with advanced non small-cell lung cancer （NSCLC）. Methods： Eightypatients were randomized into the observation group and the control group, 40 cases each group. The control groupaccepted chemotherapy, while the observation group took essence-supplementing detoxifying prescription on thefoundation of the therapy the control group received. The indexes of chemotherapy cycle, toxic and side effects, KPSimprovement rate before and after treating, body mass increase stabilization rate, clinical benefit rate and diseasecontrol rate of both groups were observed. Results： The difference had no statistical meaning in the comparisons ofdisease control rate between both groups（P〉0.05）. The observation group was superior to the control group in clinicalbenefit rates body mass increase stabilization rate and KPS scores after treating（P〈0.05）, the observation group wasless than the control group in the number of the coser suffering adverse reactions, longer than the control group inoverage chemollerapy cycle. Conclusion： Essence-supplementing detoxifying prescription joined with chemotherapyin treating senile patients with advanced NSCLC could improve quality of life, raise disease control rate and clinicalbenefit rate, the method could reduce adverse reaction caused by chemotherapy and enhance the elderly忆s toleranceto chemotherapy.

关 键 词：肺癌 补精解毒方 化疗 中晚期 老年人 

分 类 号：R734.2[医药卫生—肿瘤]