丹参合剂联合四联疗法治疗慢性萎缩性胃炎伴幽门螺杆菌感染48例  

Treating 48 Cases of Chronic Atrophic Gastritis Accompanying HP-infection by DanShen Mixture Joined with Quadruple Therapy

作　　者：张伟[1] 张振榆 ZHANG Wei;ZHANG Zhenyu(Yulin Municipality the Second Hospital,Yulin 719000,China)

机构地区：[1]榆林市第二医院,陕西榆林719000

出　　处：《西部中医药》2018年第10期91-94,共4页Western Journal of Traditional Chinese Medicine

摘　　要：目的:观察丹参合剂联合四联疗法治疗慢性萎缩性胃炎伴幽门螺杆菌(Hp)感染的临床疗效。方法:将96例患者按照就诊先后顺序分为观察组和对照组,每组48例。对照组给予铋剂四联疗法治疗,观察组在此基础上加服丹参合剂,2组均连续治疗2周。对比2组Hp根除率、临床疗效、炎性因子[白细胞介素2(IL-2)、白细胞介素6(IL-6)及白细胞介素8(IL-8)]表达水平及不良反应发生情况。结果:Hp根除率观察组为93.75%(45/48),对照组为77.08%(37/48),2组比较差异有统计学意义(P<0.05)。显效率、总有效率观察组分别为61.42%、95.83%,对照组分别为33.33%、77.08%,2组比较差异均有统计学意义(P<0.05)。血清IL-2、IL-6、IL-8水平治疗前后2组组内比较,差异有统计学意义(P<0.05);治疗后2组组间比较差异也有统计学意义(P<0.05)。不良反应发生率观察组为8.33%,对照组为27.08%,2组比较差异有统计学意义(P<0.05)。结论:丹参合剂联合四联疗法治疗萎缩性胃炎伴Hp阳性疗效好,安全性高。Objective： To observe clinical effects of DanShen mixture and quadruple therapy in treating chronicatrophic gastritis （CAG） accompanying helicobacter pylori （Hp）-infection. Methods： A total of 96 patients wereallocated to the observation group and the control group according to visiting order, 48 cases each group. The controlgroup were treated with quadruple therapy of bismuth agent, and the observation group took DanShen mixturesimultaneously, both groups were treated for two weeks. The incidence of adverse reaction, the expressions ofinflammatory factors （IL-8, IL-6 and IL-2）, clinical effects, Hp eradication rate of the patients were comparedbetween both groups. Results： Hp eradication rate of the observation group was 93.75% （45/48）, higher than 77.08%（37/48） of the control group, and the difference was statistically significant in the comparisons between both groups（P〈0.05）. The effectual rate and total effective rate of the observation group were 61.42% and 95.83%, higher than33.33% and 77.08% of the control group respectively, and there was a significant difference（P〈0.05）. Thedifference had statistical meaning in the comparisons of the levels of IL-2, IL-6 and IL-8 within two groups beforeand after treating（P〈0.05）; the difference had statistical meaning in the comparison between both groups after treat-ing（P〈0.05）. The incidence of adverse reaction in the observation group was 8.33%, lower than 27.08% of the con-trol group, and the difference was statistically significant（P〈0.05）. Conclusion： DanShen mixture and quadrupletherapy could obtain good effects in treating CAG accompanying Hp-infection with high safety.

关 键 词：胃炎 萎缩性 慢性 幽门螺杆菌 丹参合剂 四联疗法 

分 类 号：R573.32[医药卫生—消化系统]