植物雌激素防治肿瘤作用及机制的研究进展  

Recent Developments in the Mechanism of Phytoestrogen in Preventing and Treating Tumor

作　　者：牛蜜蜜 田晶[1] NIU Mimi;TIAN Jing(Faculty of Basic Medicine,Guilin Medical University,Guilin 541000,China)

机构地区：[1]桂林医学院基础医学院,广西壮族自治区桂林市541000

出　　处：《中国全科医学》2018年第35期4295-4298,4304,共5页Chinese General Practice

基　　金：国家自然科学基金资助项目(81460403)

摘　　要：植物雌激素是一类天然非甾体化合物,广泛存在于各种植物中,并可以从植物中提取纯化。大多数植物雌激素由于与雌二醇化学结构相似,可与雌激素受体相互结合实现类雌激素或抗雌激素的生物学效应。植物雌激素对各类肿瘤的发生具有抑制作用,通过抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡、抑制肿瘤细胞侵袭转移、抑制肿瘤血管新生、抑制肿瘤炎症、抑制肿瘤新陈代谢、抑制肿瘤应激反应以及抑制肿瘤微环境等途径来发挥抗肿瘤作用。本文通过对植物雌激素的抗肿瘤作用及机制进行综述,提出植物雌激素将来可发挥激素替代疗法的作用,以期植物雌激素为肿瘤防治发挥更大的作用。Phytoestrogens,a class of natural non-steroidal compounds,are widely distributed among plant species and can be extracted from plant material.Most of them have the molecular level structure similar to that of estradiol and can bind to estrogen receptors in various cells and exert estrogenic or antigenic effects.Phytoestrogens have been suggested to be anticarcinogenic.The mechanisms by which they can exert inhibitory effects on tumor development may involve inhibition of cancer cell proliferation,induction of cancer cell apoptosis,suppression of cancer cell invasion and metastasis,inhibition of tumor angiogenesis,suppression of tumor-promoting inflammation,regulation of tumor metabolism and stress response,and modulation of tumor microenvironment.In this paper,the mechanisms of action of phytoestrogens on cancers were reviewed,suggesting that they may play a role in the prevention and treatment of cancers as an alternative to estradiol in the future.

关 键 词：肿瘤 植物雌激素类 机制 综述 

分 类 号：R739.9[医药卫生—肿瘤]