口服辅酶Q10改善偏头痛患者的临床症状和降低炎性因子水平的研究  

Clinical study of coenzyme Q10 for improving the symptoms and inflammatory markers in migraine patients

作　　者：贾翠娜 李艳彬 任雅慧 Jia Cuina;Li Yanbin;Ren Yahui(Department of the Central Hospital,the Tongchuan Mining Bureau,Shanxi 727000,China)

机构地区：[1]铜川矿务局中心医院门诊部双向转诊办公室,陕西727000

出　　处：《脑与神经疾病杂志》2018年第12期758-762,共5页Journal of Brain and Nervous Diseases

摘　　要：目的评估抗炎剂辅酶Q10在改善偏头痛症状和血清炎性因子的有效性。方法本研究纳入60例发作性偏头痛的女性患者,随机分为辅酶Q10治疗组和安慰剂组,分别给予辅酶Q10胶囊40mg·d-1和安慰剂胶囊(小麦淀粉)40mg·d-1,为期12w。记录患者治疗前后的偏头痛发作频率、偏头痛严重程度(VAS评分)和偏头痛持续时间等,并通过ELISA法检测患者血清中的辅酶Q10、降钙素基因相关肽(CGRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)和白介素10(IL-10)的水平。结果与安慰剂组相比,口服补充辅酶Q10能够显著降低患者的头痛频率(-5.4±1.3次/每月vs-1.5±2.2次/每月,P<0.001)、VAS评分(-3.9±1.2分vs-2.0±1.5分,P<0.001)、偏头痛持续时间(-7.1±3.0h vs-4.9±3.9h,P=0.026),并且口服辅酶Q10能够显著提高血清辅酶10水平、并降低血清CGRP、IL-6和TNF-α水平。结论口服补充辅酶Q10能够有效改善患者的偏头痛症状,并降低血清炎性因子水平。Objective To evaluate migraine is associated with an inflammatory response.This study was designed to evaluate the effeiciency of the anti-inflammatory agent-coenzyme Q10 for improving migraine symptoms and serum inflammation markers. MethodSixty female patients with episodic migraines were enrolled in this study. They were randomized into coenzyme Q10 treatment group and placebo treatment group, whom were given coenzyme Q10 capsule 40mg·d-1 and placebo capsule （wheat starch） 40mg·d-1 over 12w . The frequency of migraine attacks, sever degree （VAS score） and duration of migraine were recorded before and after treatment. The serum levels of coenzyme Q10, calcitonin gene-related peptide （CGRP）, tumor necrosis factor-α （TNF-α）, interleukin-6 （IL-6） and interleukin-10 （IL-10） were measured by ELISA before and after treatment. Results Compared with placebo treatment group, oral coenzyme Q10 supplementation significantly reduced the frequency of headache in patients （-5.4±1.3 times/month vs -1.5±2.2 times/month, P〈0.001）, VAS score （-3.9±1.2 vs -2.0±1.5, P〈0.001） and duration of migraine （-7.1±3.0h vs -4.9±3.9h, P=0.026）. Oral coenzyme Q10 supplementation could significantly increase serum coenzyme Q10 level and decrease serum CGRP, IL-6 and TNF-α levels. Conclusion Oral coenzyme Q10 supplementation can effectively improve the migraine symptoms and reduce the level of serum inflammatory markers.

关 键 词：偏头痛 辅酶Q10 炎性因子 降钙素相关基因肽 

分 类 号：R741.05[医药卫生—神经病学与精神病学]