5-氨基酮戊酸光动力疗法联合CO_2激光长期间断治疗乳房外Paget病1例  

5-Aminolevulinic acid-photodynamic therapy in combination with CO_2 laser therapy for a case report of long-term extramammary Paget's disease

作　　者：周细平 黄进华[1] 鲁建云[1] 陈静[1] 左成忻[1] 杨盛波[1] 向亚平[1] 谭丽娜[1] 康健[1] 丁澍[1] ZHOU Xiping;HUANG Jinghua;LUJianyun;CHENJing;ZUO Chengxin;YANG Shengbo;XIANG Yaping;TAN Lina;KANG Jian;DING Shu(Department of Dermatology,Third Xiangya Hospital,Central South University,Changsha 410013)

机构地区：[1]中南大学湘雅三医院皮肤科,长沙410013

出　　处：《临床与病理杂志》2018年第10期2274-2277,共4页Journal of Clinical and Pathological Research

摘　　要：患者,女,78岁,外阴部皮损14年余。依据典型的临床表现和组织病理诊断为乳房外Paget病(extramammary Paget’s disease,EMPD)。该病病程缓慢,晚期可发生转移,其首选治疗方法为手术切除。患者拒绝手术治疗,因此采用5-氨基酮戊酸光动力疗法(5-aminolevulinic acid-photodynamic therapy,AL A-PDT)联合CO2激光治疗。经长期随访发现多次治疗后表面皮损基本消退,但难以防止肿瘤复发,复发后该治疗方法仍有效。A 78-year-old female presented with lesions of the vulva for more than 14 years. The diagnosis of extramammary Paget＇s disease（EMPD） was established according to the typical clinical manifestations and histopathological exemination. The disease has a slow course and metastasis can occur in the late stage. The preferred treatment is surgical resection. Because the patient refused to surgical treatment, we used 5-aminolevulinic acid-photodynamic therapy（ALA-PDT） in combination with CO2 laser therapy. After a long-term follow-up, we found the lesion gradually subsided with multiple treatment, but it was difficult to prevent tumor recurrence, and the treatment is still effective after recurrence.

关 键 词：乳房外PAGET病 光动力疗法 CO2激光 5-氨基酮戊酸 

分 类 号：R739.5[医药卫生—肿瘤]