草铵膦的合成新工艺  

New Synthetic Process for Glufosinate

作　　者：杜辉[1] 孙春楼 邢柳 DU Hui;SUN Chun-lou;XlNG Liu(Nantong Jiang Shan Agrochemical ＆ Chemicals Co.,Ltd.,Nantong 226017,Jiangsu,China)

机构地区：[1]南通江山农药化工股份有限公司,江苏南通226017

出　　处：《农药》2018年第11期799-801,共3页Agrochemicals

摘　　要：[目的]草铵膦合成新工艺研究。[方法]以(3-乙酰氧基-3-氰基)丙基甲基次膦酸异丁酯为初始原料,经氨化得到(3-氨基-3-氰基)丙基甲基次膦酸异丁酯,再经酸解、提纯制得含量为97%草铵膦原药。[结果]草铵膦的收率可达75%。[结论]合成草铵膦的新工艺具有操作简单、收率高的优点,同时副产盐仅为氯化铵,方便回收利用,减少了三废排放。[Aims] A new synthetic method for glufosinate was studied. [Methods] Using 1-cyano-3-（isobutoxy（methyl）phosphoryl）propyl acetate as starting material, isobutyl（3-amino-3-cyanopropyl）（methyl）phosphinate was obtained by amination reaction and then subjected to acid hydrolysis and purification process to synthesis glufosinate 97% TC.[Results] The yield of glufosinate was up to 75%. [Conclusions] The new process has the advantages of simple operation, high yield, and the by-product salt is only ammonium chloride, which is convenient to recycle and reduce the discharge of three wastes.

关 键 词：氨化 酸解 提纯 草铵膦 

分 类 号：TQ460.3[化学工程—制药化工]