吉西他滨与吡柔比星行膀胱灌注预防膀胱肿瘤复发有效性及安全性的Meta分析  

Efficacy and safety of gemcitabine and pirarubicin bladder irrigation in prevention of recurrence of bladder tumor： a Meta analysis

作　　者：霍倩[1,2] 段靳岚 马玉梅[1,2] 苏文华[3] 李燕[1,2] Huo Qian;Duan Jinlan;Ma Yumei(Department of Cadre Health Care;Department of Geriatrics,the First People＇s Hospital of Yunnan Province,Kunming 650000,China)

机构地区：[1]云南省第一人民医院干部保健科,云南昆明650000 [2]云南省第一人民医院老年医学科,云南昆明650000 [3]云南省第一人民医院心内科,云南昆明650000

出　　处：《国际泌尿系统杂志》2018年第6期912-916,共5页International Journal of Urology and Nephrology

摘　　要：目的 评价吉西他滨与吡柔比星行膀胱灌注预防膀胱肿瘤复发的有效性和安全性.方法 通过计算机选取检索建库至2016年12月期间,PubMed、The Cochrance Library、Embase、中国知网和万方数据库中发表有关吉西他滨与吡柔比星行膀胱灌注预防膀胱肿瘤复发有效性与安全性的前瞻性队列研究.同时,手工检索纳入文献的参考文献,查找相关研究.筛选文献、提取资料和评估纳入研究的质量后,采用STATA 12.0软件进行荟萃分析.结果 ①共纳入7个符合要求的RCT研究,共包括618例患者;②所纳入的研究根据随机方法、分配隐藏、盲法、退出或失访、意向性分析和基线情况的描述对纳入研究进行质量评分,结果质量均为B级;③Meta分析结果显示膀胱灌注吉西他滨,随访3个月～2年时膀胱癌复发率与吡柔比星比较,（OR =0.57,P＜0.05）,两组比较差异有统计学意义,膀胱灌注吉西他滨后出现膀胱刺激症状与吡柔比星比较（OR=0.49,P＜0.05）,两组比较差异有统计学意义,膀胱灌注吉西他滨后出现血尿与吡柔比星比较（OR=0.49,P＜0.05）,两组比较差异有统计学意义.结论 本研究结果显示膀胱癌术后推荐使用吉西他滨膀胱灌注预防膀胱肿瘤复发,效果好,副反应小.Objective To evaluate the efficacy and safety of gemcitabine and pirarubicin bladder irrigation in prevention of recurrence of bladder tumor.Methods The randomized controlled trials of gemcitabine and pirarubicin bladder irrigation in prevention of recurrence of bladder tumor were performed by searching the database,such as PubMed、The Cochrance Library,Embase,Wanfang and CNKI from creating the database to December 2016.At the same time,the reference literature was searched by hand to find the relevant research.The STATA 12.0 software was assembled to analyze the quality of the selected literature,extract data and evaluation.Results ①A total of seven tudies（618 patients） on gemcitabine and pirarubicin in bladder irrigation were included.②In term of randomization,location concealment and blinding,patients quit or lost,intent-to-treat （ITT） analysis,and group baseline,all the studies were grade B.③The Meta analysis results showed that there was significant difference in recurrence rate after followed up for 3 month to 2 years between gemcitabine in bladder irrigation and pirarubicin （OR =0.57,P ＜ 0.05）,irritation sign of bladder （OR =0.49,P ＜ 0.05） and hematuria at the end of the event （OR =0.49,P ＜ 0.05）.Conclusions The results indicate that bladder irrigation of gemcitabine is better than pirarubicin in prevention of recurrence of bladder tumor with less side effects.

关 键 词：膀胱肿瘤 化学疗法 肿瘤 局部灌注 META分析 肿瘤复发 局部 

分 类 号：R737.14[医药卫生—肿瘤]