非编码RNA通过调控NOTCH信号通路影响CSCs  

Non-coding RNAs Regulate NOTCH Signaling Pathway in Cancer Stem Cells

作　　者：郭静 王会敏[1] 李平[1] 李艳利[1] GUO Jing;WANG Hui-min;LI Ping;LI Yan-li(School of Life Science,Shanghai University,Shanghai 200444,China)

机构地区：[1]上海大学生命科学学院,上海200444

出　　处：《药物生物技术》2018年第5期452-456,共5页Pharmaceutical Biotechnology

基　　金：国家自然基金资助项目(No.81601887)

摘　　要：恶性肿瘤称为癌症,严重威胁着人类的生命和健康。癌症干细胞具有"自我复制"、"高转移性"和"多细胞分化"等能力,对抗癌药物容易产生耐药性,因此靶向癌症干细胞的治疗更加有效。NOTCH信号通路是一条进化上保守的信号通路,可以调节细胞的增殖、凋亡和干细胞的新陈代谢,对癌症干细胞的生长也有着重要的影响。文章综述了非编码RNA和NOTCH通路对于癌症干细胞的调控关系,可以为癌症的临床治疗提供新的思路。Tumor is a neogrowth formed by local tissue cells when organism is undergoing the action of various tumor inducing factors. According to the cell characteristics and the degree of harm to the body of the neogrowth,tumor can be divided into two categories： benign tumor and malignant tumor. Malignant tumors are serious threat to human life and health. Cancer stem cells have the ability of‘self replicating＇,‘high metastatic＇and‘multicellular differentiation＇,which are easy to have the ability of drugs resistance. Therefore,the treatment of cancer stem cells will be more effective in clinical treatments of cancer. Non-coding RNAs,also called ncRNAs for short,act as founctional regulators mediating regulation of cells. Studies have shown that lots of ncRNAs,especially miRNAs and lncRNAs,take parts in NOTCH signaling pathway,and play very important roles in various cancer stem cells.NOTCH signaling pathway is an evolutionary conserved signaling pathway that regulates cell proliferation,apoptosis and stem cell metabolism. It also plays an important role in the growth of cancer stem cells. We summarize the internal mechanism among non-coding RNA,NOTCH pathway and cancer stem cells,and their interactions can provide new ideas for the clinical treatment of cancer.

关 键 词：非编码RNA NOTCH信号通路 癌症干细胞 信号机制 肺癌 小RNA 

分 类 号：Q811.3[生物学—生物工程]